{"id":"W4387698800","doi":"10.21203/rs.3.rs-3444133/v1","title":"Lung-derived soluble factors support stemness/plasticity and metastatic behaviour of breast cancer cells via the FGF2-DACH1 axis","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Western University","funders":"U.S. Department of Defense","keywords":"CD44; Cancer research; Metastasis; Cancer stem cell; Triple-negative breast cancer; Lung cancer; Tumor microenvironment; Breast cancer; Biology; Stem cell; Primary tumor; Medicine; Pathology; Cancer; Cell; Internal medicine; Cell biology; Tumor cells","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001531403,0.000487335,0.0006110247,0.0003328358,0.0003304858,0.0001677834,0.001105885,0.0004647292,0.0004080154],"category_scores_gemma":[0.0002827237,0.0003641711,0.000279668,0.0004042342,0.0008897225,0.00001127905,0.003929821,0.001546424,0.00002600356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001535001,"about_ca_system_score_gemma":0.001070011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005179133,"about_ca_topic_score_gemma":0.0009341066,"domain_scores_codex":[0.9945413,0.0009710699,0.0005654287,0.001142984,0.001612015,0.001167176],"domain_scores_gemma":[0.9968018,0.0004096378,0.0002200936,0.001085886,0.001106374,0.0003762229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004463413,0.0002962138,0.1338399,0.004609701,0.0007431778,0.00004621823,0.0007769794,0.000500097,0.8481193,0.00001459905,0.01026892,0.0003385168],"study_design_scores_gemma":[0.0009895882,0.0008293922,0.4241403,0.0006746826,0.0001631698,0.00002230407,0.001749481,0.001009275,0.5689898,0.0001702062,0.0004557504,0.0008059993],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932885,0.0005207655,0.0004374988,0.0003631703,0.0002971949,0.001769667,0.003237912,0.00003414137,0.00005116593],"genre_scores_gemma":[0.9962461,0.0008346716,0.00006334912,0.000008127975,0.0001607521,0.0004153348,0.0006274858,0.0001347915,0.001509386],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2903004,"threshold_uncertainty_score":0.999881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0613002267548441,"score_gpt":0.3790550467763972,"score_spread":0.3177548200215531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}