{"id":"W4387700505","doi":"10.7554/elife.87894.2.sa1","title":"eLife Assessment: Identifying metabolic features of colorectal cancer liability using Mendelian randomization","year":2023,"lang":"en","type":"peer-review","venue":"","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; NIHR Imperial Biomedical Research Centre; Instituto de Salud Carlos III; Cancer Council Victoria; Ontario Ministry of Research and Innovation; National Health and Medical Research Council; Medical Research Council; Chonnam National University Hwasun Hospital; Biobanco Vasco; Junta de Castilla y León; Xunta de Galicia; School of Public Health, Imperial College London; Elizabeth Blackwell Institute for Health Research, University of Bristol; Deutsche Krebshilfe; Associazione Italiana per la Ricerca sul Cancro; Vetenskapsrådet; Stockholms Läns Landsting; Mutuelle Générale de l'Education Nationale; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Imperial College London; Generalitat de Catalunya; Wereld Kanker Onderzoek Fonds; National Cancer Institute; Fundación Científica Asociación Española Contra el Cáncer; University of Cambridge; ZonMw; Canadian Cancer Society Research Institute; Marshfield Clinic Research Foundation; Institut National de la Santé et de la Recherche Médicale; World Cancer Research Fund; Knut och Alice Wallenbergs Stiftelse; Damon Runyon Cancer Research Foundation; University of Bristol; Chonnam National University; Centres de Recerca de Catalunya; Umeå Universitet; European Commission; Division of Cancer Prevention, National Cancer Institute; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Institute for Health and Care Research; Memorial Sloan-Kettering Cancer Center; Wellcome Trust; Cancer Research UK; UK Research and Innovation; Génome Québec; University of South Florida; Swedish Cancer Foundation; National Heart, Lung, and Blood Institute; Florida Department of Health; National Institutes of Health; Mike and Josie Harper Cancer Research Institute; Cancerfonden; Canadian Institutes of Health Research; Diabetes UK; Institut Gustave-Roussy; Herzfelder'sche Familienstiftung; Pelotonia; Moffitt Cancer Center; World Cancer Research Fund International; Johns Hopkins University; McGill University; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; Emory University; U.S. Department of Health and Human Services","keywords":"Mendelian randomization; Colorectal cancer; Medicine; Internal medicine; Oncology; Cancer; Polyunsaturated fatty acid; Biology; Bioinformatics; Genetics; Fatty acid; Endocrinology; Genotype; Gene; Genetic variants; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.03510761,0.001439843,0.002506007,0.002741723,0.0007648264,0.00154609,0.002086146,0.001834039,0.01571059],"category_scores_gemma":[0.08638047,0.0007968814,0.00274544,0.002117009,0.001525721,0.001394594,0.001781893,0.001583982,0.0009862657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006202607,"about_ca_system_score_gemma":0.001341455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003048993,"about_ca_topic_score_gemma":0.002257971,"domain_scores_codex":[0.9411994,0.04755394,0.001421692,0.006301662,0.002452566,0.0010708],"domain_scores_gemma":[0.950091,0.03799309,0.003365955,0.007226263,0.0008170436,0.0005066571],"domain_codex":null,"domain_gemma":"evaluation","domain_candidate":"evaluation","domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.02715873,0.0009839794,0.4006908,0.001591793,0.02047374,0.007754169,0.002131158,0.02547987,0.01797216,0.08031779,0.01796169,0.397484],"study_design_scores_gemma":[0.007204406,0.009640704,0.231264,0.0004756952,0.01083587,0.00944789,0.0006669477,0.5472204,0.01560568,0.122717,0.04451957,0.0004017301],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"other","genre_scores_codex":[0.282234,0.000708266,0.701544,0.001180411,0.0003800131,0.001571347,0.003655258,0.00352946,0.005197174],"genre_scores_gemma":[0.6982583,0.0002377275,0.2930844,0.0003936468,0.00009857804,0.002752121,0.001207155,0.0003888811,0.003579244],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.9648924,"threshold_uncertainty_score":0.185669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0337887307888854,"score_gpt":0.3706102140613786,"score_spread":0.3368214832724932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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