{"id":"W4387700529","doi":"10.7554/elife.87894.2.sa0","title":"Joint Public Review: Identifying metabolic features of colorectal cancer liability using Mendelian randomization","year":2023,"lang":"en","type":"peer-review","venue":"","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; NIHR Imperial Biomedical Research Centre; Instituto de Salud Carlos III; Cancer Council Victoria; Ontario Ministry of Research and Innovation; National Health and Medical Research Council; Medical Research Council; Chonnam National University Hwasun Hospital; Biobanco Vasco; Junta de Castilla y León; Xunta de Galicia; School of Public Health, Imperial College London; Elizabeth Blackwell Institute for Health Research, University of Bristol; Deutsche Krebshilfe; Associazione Italiana per la Ricerca sul Cancro; Vetenskapsrådet; Stockholms Läns Landsting; Mutuelle Générale de l'Education Nationale; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Imperial College London; Generalitat de Catalunya; Wereld Kanker Onderzoek Fonds; National Cancer Institute; Fundación Científica Asociación Española Contra el Cáncer; University of Cambridge; ZonMw; Canadian Cancer Society Research Institute; Marshfield Clinic Research Foundation; Institut National de la Santé et de la Recherche Médicale; World Cancer Research Fund; Knut och Alice Wallenbergs Stiftelse; Damon Runyon Cancer Research Foundation; University of Bristol; Chonnam National University; Centres de Recerca de Catalunya; Umeå Universitet; European Commission; Division of Cancer Prevention, National Cancer Institute; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Institute for Health and Care Research; Memorial Sloan-Kettering Cancer Center; Wellcome Trust; Cancer Research UK; UK Research and Innovation; Génome Québec; University of South Florida; Swedish Cancer Foundation; National Heart, Lung, and Blood Institute; Florida Department of Health; National Institutes of Health; Mike and Josie Harper Cancer Research Institute; Cancerfonden; Canadian Institutes of Health Research; Diabetes UK; Institut Gustave-Roussy; Herzfelder'sche Familienstiftung; Pelotonia; Moffitt Cancer Center; World Cancer Research Fund International; Johns Hopkins University; McGill University; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; Emory University; U.S. Department of Health and Human Services","keywords":"Mendelian randomization; Colorectal cancer; Internal medicine; Medicine; Oncology; Polyunsaturated fatty acid; Cancer; Biology; Endocrinology; Genetics; Fatty acid; Bioinformatics; Genotype; Gene; Genetic variants; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.07714371,0.001382591,0.005533892,0.01133474,0.001261448,0.006963977,0.003206591,0.007261186,0.03224678],"category_scores_gemma":[0.2885037,0.002002978,0.003243764,0.01205684,0.002157729,0.002357882,0.002965429,0.00287152,0.009716571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004025465,"about_ca_system_score_gemma":0.01255754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004885535,"about_ca_topic_score_gemma":0.004842539,"domain_scores_codex":[0.918615,0.05176834,0.008301147,0.005672163,0.0142207,0.001422642],"domain_scores_gemma":[0.747074,0.1245945,0.03724781,0.0287371,0.05767448,0.004672114],"domain_codex":null,"domain_gemma":"evaluation","domain_candidate":"evaluation","domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009864368,0.00005865484,0.004985503,0.02354035,0.005626689,0.0003490262,0.00009169437,0.00052478,0.0002251324,0.003652144,0.7925655,0.167394],"study_design_scores_gemma":[0.001747929,0.0002892395,0.02903036,0.03154835,0.0108046,0.001446725,0.0001101201,0.003121847,0.0004723244,0.01296792,0.9082287,0.0002319172],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"other","genre_scores_codex":[0.003113073,0.5574175,0.02302786,0.1997033,0.1620115,0.003061683,0.02175723,0.002210903,0.02769689],"genre_scores_gemma":[0.118758,0.498421,0.02364205,0.09198471,0.1997273,0.01175278,0.01854032,0.001974549,0.03519922],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.9228563,"threshold_uncertainty_score":0.4079798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05393269694177952,"score_gpt":0.3467141300846652,"score_spread":0.2927814331428857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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