{"id":"W4387701134","doi":"10.1093/jnci/djad215","title":"Loss of feedback regulation between FAM3B and androgen receptor driving prostate cancer progression","year":2023,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute; National Institutes of Health; Johns Hopkins University; School of Medicine, Duke University; University of Washington; Tulane University; Vanderbilt University; National Institute on Minority Health and Health Disparities; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs; U.S. Department of Defense","keywords":"TMPRSS2; Prostate cancer; Biology; Cancer research; Fusion gene; Androgen receptor; Prostate; Epigenetics; Cancer; Internal medicine; Genetics; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000271994,0.0002504851,0.0003482825,0.0004613395,0.0002900914,0.0005024844,0.0002551854,0.000257308,0.001699847],"category_scores_gemma":[0.0003764598,0.0001963713,0.000362281,0.0004650299,0.0002643943,0.0001925373,0.0003686202,0.0004830115,0.0004120798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005617831,"about_ca_system_score_gemma":0.0006311975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002212223,"about_ca_topic_score_gemma":0.003300651,"domain_scores_codex":[0.9997527,0.00002155565,0.00001109296,0.0000669213,0.00009651171,0.00005122229],"domain_scores_gemma":[0.9996508,0.00006128648,0.0001356829,0.00003500868,0.00004871555,0.00006842244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001798137,0.00001836997,0.01642097,0.000050826,0.00002879509,0.00007924117,0.00002162914,0.0003298411,0.9783058,0.00011618,0.0001274047,0.00432111],"study_design_scores_gemma":[0.00002814565,0.0004021059,0.4156977,0.00003322224,0.0001336077,0.001873586,0.0001877482,0.009387787,0.5633349,0.0004711087,0.008419717,0.0000302169],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881953,0.002968061,0.006200945,0.0001114239,0.00001893298,0.00001749362,0.001459656,0.0001727664,0.0008555301],"genre_scores_gemma":[0.9960562,0.0004860914,0.001545774,0.00007690365,0.000006810404,0.00001756833,0.001252906,0.00002735685,0.0005303961],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002212223,"threshold_uncertainty_score":0.005686522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06664239225078174,"score_gpt":0.3980868318259597,"score_spread":0.331444439575178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}