{"id":"W4387706708","doi":"10.3390/biomedicines11102815","title":"Epigenetics in Heart Failure: Role of DNA Methylation in Potential Pathways Leading to Heart Failure with Preserved Ejection Fraction","year":2023,"lang":"en","type":"review","venue":"Biomedicines","topic":"Cardiovascular Function and Risk Factors","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Heart failure; Epigenetics; Heart failure with preserved ejection fraction; Ejection fraction; DNA methylation; Cardiology; Medicine; Internal medicine; Atrial fibrillation; Biology; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007651543,0.0003874405,0.00202967,0.002039928,0.00004309247,0.00001612833,0.00008296379,0.0004861864,0.00004835775],"category_scores_gemma":[0.0002328562,0.0002826363,0.0004717307,0.002591601,0.0000642735,0.00008779431,0.00004559802,0.0004727695,0.00007081592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002922132,"about_ca_system_score_gemma":0.0002674717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006069739,"about_ca_topic_score_gemma":0.0007962238,"domain_scores_codex":[0.9973105,0.0002561659,0.0008873125,0.0005486169,0.0006778609,0.000319534],"domain_scores_gemma":[0.9988695,0.0001151092,0.0002404083,0.0004565108,0.0001537555,0.0001646596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001173279,0.00129793,0.0854094,0.07118399,0.003562639,0.0002953971,0.001292197,0.0008442216,0.04680615,0.00003410182,0.02891031,0.7591904],"study_design_scores_gemma":[0.001085116,0.0004835008,0.01097818,0.01345931,0.0008271906,0.0000970835,0.000799966,0.00003531701,0.0004222156,0.000009348523,0.9715044,0.0002983127],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02475898,0.9670311,0.0009246669,0.001059771,0.001412371,0.004461682,0.00005218968,0.0002416572,0.00005760954],"genre_scores_gemma":[0.02074797,0.9741791,0.001609764,0.00007309151,0.001631685,0.0003184101,0.0009042012,0.000222469,0.0003132381],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9425942,"threshold_uncertainty_score":0.9999626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03705949081463675,"score_gpt":0.3045846853697198,"score_spread":0.2675251945550831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}