{"id":"W4387710687","doi":"10.1016/s2468-1253(23)00250-9","title":"Rusfertide for the treatment of iron overload in HFE-related haemochromatosis: an open-label, multicentre, proof-of-concept phase 2 trial","year":2023,"lang":"en","type":"article","venue":"˜The œLancet. Gastroenterology & hepatology","topic":"Iron Metabolism and Disorders","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Protagonist Therapeutics","keywords":"Hepcidin; Phlebotomy; Hemochromatosis; Medicine; Internal medicine; Hereditary hemochromatosis; Gastroenterology; Anemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005039226,0.000324902,0.001503148,0.000198154,0.0001167362,0.00001054562,0.0006111808,0.0002289385,0.00007266078],"category_scores_gemma":[0.00009194349,0.0002016737,0.0001429672,0.0002909178,0.0006565884,0.00009087186,0.0001111269,0.0002167846,0.000008646527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000586282,"about_ca_system_score_gemma":0.0001230837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004058256,"about_ca_topic_score_gemma":0.001795648,"domain_scores_codex":[0.9969575,0.0005293637,0.0009492021,0.0005149473,0.0001701817,0.0008787657],"domain_scores_gemma":[0.998129,0.0003829768,0.0004056221,0.0008943746,0.00008192653,0.0001060723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6184409,0.02789326,0.2604075,0.0004038961,0.001225419,0.0002439261,0.009236321,0.0003137012,0.01080049,0.001032865,0.009576775,0.06042489],"study_design_scores_gemma":[0.877827,0.05527272,0.02931589,0.00009915278,0.001871922,0.000179517,0.001875889,0.01952671,0.005829004,0.0005605281,0.007318007,0.0003236094],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887519,0.001055906,0.0002080549,0.004702749,0.000843843,0.004203151,0.0001303126,0.00005604012,0.00004808431],"genre_scores_gemma":[0.9969463,0.0003884608,0.000247397,0.00103884,0.0001824709,0.0008395736,0.0001958581,0.000040641,0.0001204087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2593861,"threshold_uncertainty_score":0.8224013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05753506721151899,"score_gpt":0.3554788820062103,"score_spread":0.2979438147946912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}