{"id":"W4387710687","doi":"10.1016/s2468-1253(23)00250-9","title":"Rusfertide for the treatment of iron overload in HFE-related haemochromatosis: an open-label, multicentre, proof-of-concept phase 2 trial","year":2023,"lang":"en","type":"article","venue":"˜The œLancet. Gastroenterology & hepatology","topic":"Iron Metabolism and Disorders","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Protagonist Therapeutics","keywords":"Hepcidin; Phlebotomy; Hemochromatosis; Medicine; Internal medicine; Hereditary hemochromatosis; Gastroenterology; Anemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00246683,0.001382451,0.00193459,0.0002607454,0.0002845776,0.00113182,0.0006552378,0.002016253,0.006342563],"category_scores_gemma":[0.001676199,0.0003234865,0.001688443,0.0002553775,0.0007323917,0.001163949,0.0003041736,0.003720607,0.0009726495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005888273,"about_ca_system_score_gemma":0.0007943027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004112753,"about_ca_topic_score_gemma":0.0009025748,"domain_scores_codex":[0.9995245,0.0002652913,0.0000199176,0.00005236351,0.00004762789,0.00009037453],"domain_scores_gemma":[0.9991871,0.0003633658,0.0001355211,0.00005163671,0.00005720723,0.000205271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8910344,0.004735243,0.0006274688,0.002547871,0.002223943,0.0002054989,0.0001287077,0.0006775846,0.006920992,0.0006164181,0.007366637,0.08291528],"study_design_scores_gemma":[0.9397252,0.05255787,0.001803328,0.0002022174,0.000637277,0.0002165453,0.00005265707,0.0004670988,0.0006841067,0.0006064127,0.003017168,0.00003010938],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9099983,0.06409649,0.003045613,0.006291152,0.002963607,0.003335787,0.002855195,0.0004276606,0.006986307],"genre_scores_gemma":[0.96127,0.01761154,0.004055384,0.00510019,0.001328688,0.003705262,0.002034344,0.0000562159,0.004838372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006342563,"threshold_uncertainty_score":0.021218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05753506721151899,"score_gpt":0.3554788820062103,"score_spread":0.2979438147946912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}