{"id":"W4387710695","doi":"10.1016/s0140-6736(23)02179-7","title":"Once-weekly insulin icodec versus once-daily insulin degludec as part of a basal-bolus regimen in individuals with type 1 diabetes (ONWARDS 6): a phase 3a, randomised, open-label, treat-to-target trial","year":2023,"lang":"en","type":"article","venue":"The Lancet","topic":"Diabetes Management and Research","field":"Medicine","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"KU Leuven; Dexcom; Novo Nordisk; Intarcia Therapeutics; Sanofi; Pfizer; AstraZeneca; Eli Lilly and Company","keywords":"Insulin degludec; Medicine; Regimen; Basal insulin; Insulin; Type 2 diabetes; Diabetes mellitus; Internal medicine; Bolus (digestion); Endocrinology; Open label; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003252689,0.0003488486,0.001491248,0.0004401441,0.0001207362,0.0001352059,0.00115393,0.0001402425,0.0003300973],"category_scores_gemma":[0.001402632,0.0002217884,0.00008255026,0.002346335,0.000233972,0.00019015,0.0005859979,0.0004836066,0.000470535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001320754,"about_ca_system_score_gemma":0.0006259663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001246969,"about_ca_topic_score_gemma":0.00004898436,"domain_scores_codex":[0.9963625,0.0004723161,0.0006429075,0.0005662152,0.0009702363,0.0009858261],"domain_scores_gemma":[0.9973606,0.000878866,0.0002343151,0.001102372,0.000163081,0.000260782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7669612,0.003208792,0.006612409,0.0003556041,0.001360224,0.0002390362,0.002559867,0.0001274774,0.001067213,0.0003019546,0.173042,0.04416418],"study_design_scores_gemma":[0.8886358,0.01213695,0.00376181,0.0006835798,0.0003318652,9.847785e-7,0.000382544,0.000734504,0.002262025,0.0005207433,0.09013856,0.000410599],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9633136,0.0006928417,0.000002921547,0.00854202,0.000354973,0.004554385,0.0001174617,0.0001204202,0.02230138],"genre_scores_gemma":[0.9702642,0.001022727,0.001367326,0.00185806,0.001749567,0.001330471,0.0004900924,0.0001533326,0.02176423],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1216746,"threshold_uncertainty_score":0.9044269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1035823676816233,"score_gpt":0.3857179146498151,"score_spread":0.2821355469681919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}