{"id":"W4387710695","doi":"10.1016/s0140-6736(23)02179-7","title":"Once-weekly insulin icodec versus once-daily insulin degludec as part of a basal-bolus regimen in individuals with type 1 diabetes (ONWARDS 6): a phase 3a, randomised, open-label, treat-to-target trial","year":2023,"lang":"en","type":"article","venue":"The Lancet","topic":"Diabetes Management and Research","field":"Medicine","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"KU Leuven; Dexcom; Novo Nordisk; Intarcia Therapeutics; Sanofi; Pfizer; AstraZeneca; Eli Lilly and Company","keywords":"Insulin degludec; Medicine; Regimen; Basal insulin; Insulin; Type 2 diabetes; Diabetes mellitus; Internal medicine; Bolus (digestion); Endocrinology; Open label; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001491153,0.000831588,0.001661203,0.0002547078,0.0002256643,0.0007760884,0.0005573374,0.001181494,0.004562461],"category_scores_gemma":[0.001222155,0.0003008417,0.001456315,0.0003261032,0.0005435238,0.0005412759,0.000302121,0.00207849,0.0005581686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004374687,"about_ca_system_score_gemma":0.0006776533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000599273,"about_ca_topic_score_gemma":0.001472482,"domain_scores_codex":[0.9995316,0.0002562483,0.00002895282,0.00007975642,0.00004811893,0.00005534148],"domain_scores_gemma":[0.9992788,0.0002242099,0.0002001547,0.0000408516,0.00005133412,0.0002046593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9568644,0.00851774,0.001040609,0.0009244165,0.0005069152,0.00003161469,0.00006107763,0.0002678274,0.003730597,0.0001102271,0.0008438568,0.02710076],"study_design_scores_gemma":[0.9008293,0.09393474,0.002767873,0.00008568361,0.0004507306,0.0000497823,0.00002757706,0.0002775686,0.0004840252,0.00009460743,0.0009862152,0.00001196013],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845074,0.007108843,0.0004299999,0.0003915304,0.0004282475,0.003070603,0.0007610951,0.00005933724,0.003242858],"genre_scores_gemma":[0.982524,0.005363631,0.002104053,0.001487463,0.0003822578,0.003450288,0.001274373,0.00002205001,0.003391798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004562461,"threshold_uncertainty_score":0.01526296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1035823676816233,"score_gpt":0.3857179146498151,"score_spread":0.2821355469681919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}