{"id":"W4387711110","doi":"10.1016/j.cmet.2023.09.012","title":"CD36 maintains lipid homeostasis via selective uptake of monounsaturated fatty acids during matrix detachment and tumor progression","year":2023,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; National Institute on Aging; University of Alberta; Center for Clinical and Translational Science, University of Illinois at Chicago; University of Illinois at Chicago; University of Houston; U.S. Department of Veterans Affairs","keywords":"CD36; Lipotoxicity; Unfolded protein response; Endocrinology; Internal medicine; Lipid metabolism; AMPK; Chemistry; Fatty acid; Endoplasmic reticulum; Palmitoylation; Biology; Cell biology; Biochemistry; Medicine; Receptor; Insulin resistance; Protein kinase A; Enzyme; Phosphorylation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001719436,0.0001815801,0.0002907368,0.000289581,0.0003591332,0.0005790811,0.0001970773,0.0003638489,0.000898247],"category_scores_gemma":[0.0002075498,0.0001882456,0.0001982012,0.0002521177,0.0002815701,0.0003775001,0.0003916393,0.0006156775,0.0003639211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007027357,"about_ca_system_score_gemma":0.0003959374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002401595,"about_ca_topic_score_gemma":0.00333932,"domain_scores_codex":[0.9997826,0.00002899671,0.00001178121,0.00004033389,0.00003983141,0.00009644982],"domain_scores_gemma":[0.9998542,0.00001089613,0.00003121238,0.00002138206,0.00003093713,0.00005130919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007531015,0.00001605429,0.000877308,0.00001637048,0.000004889221,0.00005708536,0.0000396043,0.00003520645,0.9964557,0.0001958739,0.00006571801,0.001483046],"study_design_scores_gemma":[0.00004470756,0.0002446941,0.03228602,0.00001134438,0.00002469525,0.0003890939,0.000274995,0.001134172,0.9614592,0.0004021789,0.003717175,0.00001175672],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950106,0.002444047,0.001253054,0.0002628392,0.00002062078,0.000009170482,0.0001399255,0.00004700877,0.0008127597],"genre_scores_gemma":[0.9968772,0.0004220755,0.0004850504,0.00003762682,0.000005826786,0.000009084943,0.0001181938,0.000009371971,0.002035589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002401595,"threshold_uncertainty_score":0.00509876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006522334713367982,"score_gpt":0.2555657663857966,"score_spread":0.2490434316724286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}