{"id":"W4387730731","doi":"10.1101/2023.10.17.23297050","title":"Genome wide association study of clinical duration and age at onset of sporadic CJD","year":2023,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Public Health Agency of Canada; University of Toronto; University Health Network","funders":"Ministero della Salute; Rijksinstituut voor Volksgezondheid en Milieu; University College London Hospitals NHS Foundation Trust; Instituto de Salud Carlos III; EU Joint Programme – Neurodegenerative Disease Research; National Institute for Health and Care Research; Uniwersytet Łódzki","keywords":"Genome-wide association study; Single-nucleotide polymorphism; Genetics; Biology; Age of onset; SNP; Genetic association; Disease; Medicine; Gene; Genotype; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001494583,0.0003777108,0.0004276486,0.001088785,0.0005831139,0.0007497418,0.0004700455,0.000812165,0.002591963],"category_scores_gemma":[0.003423234,0.0002541036,0.0007009055,0.001524582,0.0003245386,0.0002744225,0.0004223993,0.0008066415,0.0002746759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001560377,"about_ca_system_score_gemma":0.0001828148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003039193,"about_ca_topic_score_gemma":0.002619797,"domain_scores_codex":[0.9989653,0.0003517825,0.00009096791,0.00038527,0.0001206086,0.0000860413],"domain_scores_gemma":[0.9969931,0.00138521,0.0006286924,0.0002742184,0.000267764,0.0004509763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00113344,0.00006086405,0.990816,0.00002604016,0.0007964371,0.0004474521,0.00008206228,0.0001903282,0.003763644,0.00006945631,0.0002301842,0.002384081],"study_design_scores_gemma":[0.00002162096,0.0001029686,0.998421,0.000005630728,0.0001641195,0.0003915312,0.00004452992,0.0004234556,0.0001729876,0.00006242466,0.0001847619,0.000005040829],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979267,0.0005089748,0.0004172351,0.00005158673,0.00001864814,0.000004910729,0.0006617114,0.00001482756,0.0003953212],"genre_scores_gemma":[0.9989644,0.00008332168,0.0001984492,0.00002166203,0.00001479284,0.000005080271,0.0004891077,0.000006964971,0.0002161723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003039193,"threshold_uncertainty_score":0.008670986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04568627039837335,"score_gpt":0.3374030078458201,"score_spread":0.2917167374474468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}