{"id":"W4387731464","doi":"10.1016/s1569-1993(23)01262-6","title":"335 Cryogenic electron microscopy studies of human CFTR folding and conformational dynamics elucidate a novel potentiator binding site in the nucleotide binding domains that supports an alternative channelgating mechanism","year":2023,"lang":"en","type":"article","venue":"Journal of Cystic Fibrosis","topic":"Neonatal Respiratory Health Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Directorate for Biological Sciences; School of Medicine, University of Alabama at Birmingham; University of North Carolina at Chapel Hill; National Institutes of Health; University of Alabama at Birmingham; McGill University; Texas Tech University","keywords":"Potentiator; Folding (DSP implementation); Mechanism (biology); Cystic fibrosis; Biophysics; Medicine; Nucleotide; Computational biology; Chemistry; Biochemistry; Biology; Physics; Pharmacology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001582407,0.0001957051,0.0002622188,0.00008515742,0.0005569923,0.0004083289,0.0004064803,0.0006369647,0.001670336],"category_scores_gemma":[0.0003309134,0.0002336829,0.0003028648,0.00008827977,0.0004150215,0.0004809026,0.0001918878,0.0007631323,0.0004182904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002719824,"about_ca_system_score_gemma":0.0002705506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00162629,"about_ca_topic_score_gemma":0.001821661,"domain_scores_codex":[0.9999524,0.000006758466,0.000002395446,0.000009098309,0.00001468437,0.00001471484],"domain_scores_gemma":[0.9998324,0.0000673665,0.00002994343,0.00002680211,0.00002011749,0.00002332064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003141318,0.00006287264,0.001261793,0.00003733289,0.00001099723,0.0003081388,0.0001029487,0.001005417,0.9937132,0.001561648,0.00009791955,0.001523607],"study_design_scores_gemma":[0.00007358489,0.000284243,0.02255707,0.00003636389,0.00004346687,0.001079171,0.0002922513,0.03085034,0.941387,0.001184122,0.002160979,0.00005153644],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925931,0.0001718878,0.006032036,0.0001235212,0.00001088494,0.000008241148,0.00007694487,0.00003866811,0.0009446977],"genre_scores_gemma":[0.9967908,0.00006753582,0.002597554,0.00005115598,0.000002480826,0.000006444439,0.0001018621,0.000009828292,0.0003722991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001670336,"threshold_uncertainty_score":0.005587816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05279236571481978,"score_gpt":0.3925636026640545,"score_spread":0.3397712369492348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}