{"id":"W4387731505","doi":"10.1016/j.drup.2023.101012","title":"Antibiotic failure: Beyond antimicrobial resistance","year":2023,"lang":"en","type":"review","venue":"Drug Resistance Updates","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":228,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Perelman School of Medicine, University of Pennsylvania; Defense Threat Reduction Agency; Killam Trusts; Brain and Behavior Research Foundation; National Institute of General Medical Sciences; United Therapeutics Corporation; International Association for Dental Research; University of British Columbia; University of Pennsylvania; National Institutes of Health; ACE Foundation; Procter and Gamble","keywords":"Antibiotic resistance; Antibiotics; Intensive care medicine; Medicine; Sepsis; Antimicrobial; Microbiome; Biology; Microbiology; Immunology; Bioinformatics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.0006349034,0.001322565,0.00240623,0.0003074488,0.0003590519,0.0003155433,0.001768848,0.0009507719,0.00005164929],"category_scores_gemma":[0.000344607,0.001242034,0.001009454,0.0009635788,0.000559817,0.0000209646,0.0005461416,0.0006088631,0.0009118116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001447889,"about_ca_system_score_gemma":0.0006163245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005691327,"about_ca_topic_score_gemma":0.001290683,"domain_scores_codex":[0.9942601,0.0003953724,0.001509339,0.002096719,0.0004989973,0.00123942],"domain_scores_gemma":[0.9960614,0.0001413793,0.001063049,0.00227685,0.0002081005,0.0002492447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001730263,0.0001503317,0.00006901849,0.046186,0.001030673,0.0002226513,0.00004143605,9.024533e-7,0.001082355,0.001084996,0.9375142,0.01244445],"study_design_scores_gemma":[0.0002886075,0.00001389371,0.0000205624,0.01279331,0.0004630923,0.00001649407,0.00003137959,1.381337e-7,0.0009143683,0.0001118733,0.9840173,0.001328991],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003516009,0.9933212,0.00004416396,0.0002397328,0.001042873,0.001193157,0.0009671331,0.0002182485,0.002621862],"genre_scores_gemma":[0.0001191512,0.9167069,0.002400936,0.000124641,0.0009940229,0.00003792693,0.00366407,0.0004378938,0.07551446],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.07661433,"threshold_uncertainty_score":0.9999526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01472030605848085,"score_gpt":0.2833561460175726,"score_spread":0.2686358399590917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}