{"id":"W4387731505","doi":"10.1016/j.drup.2023.101012","title":"Antibiotic failure: Beyond antimicrobial resistance","year":2023,"lang":"en","type":"review","venue":"Drug Resistance Updates","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":228,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Perelman School of Medicine, University of Pennsylvania; Defense Threat Reduction Agency; Killam Trusts; Brain and Behavior Research Foundation; National Institute of General Medical Sciences; United Therapeutics Corporation; International Association for Dental Research; University of British Columbia; University of Pennsylvania; National Institutes of Health; ACE Foundation; Procter and Gamble","keywords":"Antibiotic resistance; Antibiotics; Intensive care medicine; Medicine; Sepsis; Antimicrobial; Microbiome; Biology; Microbiology; Immunology; Bioinformatics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00116686,0.001315957,0.00254209,0.001889278,0.0002806891,0.001773414,0.001146959,0.002188704,0.004903125],"category_scores_gemma":[0.002279021,0.0002532332,0.0006550908,0.001662909,0.0008691624,0.001850569,0.001060156,0.004106201,0.00269094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009470048,"about_ca_system_score_gemma":0.001516547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001078833,"about_ca_topic_score_gemma":0.002657771,"domain_scores_codex":[0.9995241,0.0001224814,0.00005757172,0.0000693871,0.0001818331,0.00004470881],"domain_scores_gemma":[0.9987577,0.0006731896,0.0001297626,0.00003320907,0.0002711367,0.0001350239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009438113,0.00004604092,0.0001317854,0.00922975,0.00007451295,0.0001728361,0.00002970568,0.0002808852,0.0006023827,0.0040889,0.1128411,0.8724077],"study_design_scores_gemma":[0.0000357787,0.00007954548,0.0004332167,0.005035022,0.0001056886,0.0008252066,0.00004535793,0.0001480436,0.0001329835,0.002888537,0.9902533,0.00001726917],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002606492,0.9978624,0.0001247973,0.0007657831,0.0006902777,0.000001963475,0.000009837976,0.000009170421,0.0005096239],"genre_scores_gemma":[0.0003108074,0.9963671,0.0001945218,0.001150727,0.001357823,0.000004483863,0.00002760959,0.000003261579,0.0005835928],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004903125,"threshold_uncertainty_score":0.0164026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01472030605848085,"score_gpt":0.2833561460175726,"score_spread":0.2686358399590917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}