{"id":"W4387732847","doi":"10.1002/anie.202313503","title":"Divergent Synthesis of 1,2,3,4‐Tetrasubstituted Cyclobutenes from a Common Scaffold: Enantioselective Desymmetrization by Dual‐Catalyzed Photoredox Cross‐Coupling","year":2023,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Radical Photochemical Reactions","field":"Chemistry","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Desymmetrization; Enantioselective synthesis; Chemistry; Cyclobutane; Stereochemistry; Combinatorial chemistry; Enantiomer; Enantiomeric excess; Stereoisomerism; Tetra; Olefin fiber; Catalysis; Organic chemistry; Medicinal chemistry; Ring (chemistry)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002213649,0.0005698658,0.0002522697,0.000277828,0.0001293995,0.0003131304,0.0003894549,0.0002917122,0.001400092],"category_scores_gemma":[0.0001617267,0.0002123291,0.0002346682,0.000276997,0.0001967088,0.0003991225,0.0003475126,0.0007160464,0.0006480017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002881113,"about_ca_system_score_gemma":0.0003171252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004799325,"about_ca_topic_score_gemma":0.001365767,"domain_scores_codex":[0.9998511,0.00001722736,0.00001226349,0.00003914143,0.00002957809,0.00005063394],"domain_scores_gemma":[0.9999292,0.00000749725,0.00002129983,0.00001237515,0.00001181582,0.0000177723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000757933,0.00005366432,0.0001059133,0.0001197946,0.0000142872,0.000337798,0.00008513304,0.0005098478,0.9899719,0.00229982,0.0002336012,0.006192503],"study_design_scores_gemma":[0.00002586595,0.000229939,0.0003620431,0.00001271964,0.0000148782,0.0002431894,0.0000271237,0.001442176,0.992531,0.0001881534,0.004908488,0.00001443498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9364511,0.002385737,0.03330985,0.0002782023,0.0002122631,0.0001854787,0.0007627245,0.000319951,0.02609474],"genre_scores_gemma":[0.9830143,0.001549884,0.01136252,0.00006066406,0.00001199787,0.00005288898,0.0002392232,0.00005066014,0.003657921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001400092,"threshold_uncertainty_score":0.004683733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01373762693415224,"score_gpt":0.2715995829239025,"score_spread":0.2578619559897503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}