{"id":"W4387732847","doi":"10.1002/anie.202313503","title":"Divergent Synthesis of 1,2,3,4‐Tetrasubstituted Cyclobutenes from a Common Scaffold: Enantioselective Desymmetrization by Dual‐Catalyzed Photoredox Cross‐Coupling","year":2023,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Radical Photochemical Reactions","field":"Chemistry","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Desymmetrization; Enantioselective synthesis; Chemistry; Cyclobutane; Stereochemistry; Combinatorial chemistry; Enantiomer; Enantiomeric excess; Stereoisomerism; Tetra; Olefin fiber; Catalysis; Organic chemistry; Medicinal chemistry; Ring (chemistry)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001436571,0.0002600906,0.0003165731,0.0002074314,0.0001503129,0.0000781841,0.0003500124,0.000272686,0.001197057],"category_scores_gemma":[0.001525281,0.0002755531,0.0002091381,0.0006534815,0.0001833443,0.0004359078,0.000107699,0.0002221156,0.00007039779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003889007,"about_ca_system_score_gemma":0.00005597322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006762883,"about_ca_topic_score_gemma":0.00002263898,"domain_scores_codex":[0.9977975,0.00001004495,0.0005858609,0.0005081125,0.0008040746,0.00029435],"domain_scores_gemma":[0.9979481,0.000880114,0.0003726013,0.0002694656,0.0003786244,0.0001511183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001223523,0.0002342434,0.00405532,0.00004067954,0.0002976982,0.000009238092,0.00005324989,0.000151622,0.9872553,0.00004366298,0.007168757,0.0005679016],"study_design_scores_gemma":[0.0006062386,0.00000678709,0.002457518,0.0001721259,0.00009193429,0.000004197002,0.00006963112,0.002364902,0.9914659,0.0007407286,0.001757617,0.0002624359],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890658,0.00008362439,0.001053513,0.000179793,0.0007974397,0.0001402379,0.003101784,0.0003240794,0.005253678],"genre_scores_gemma":[0.9888367,0.0002823034,0.0001171242,0.00002770352,0.0006959059,0.000200731,0.009469057,0.00004294524,0.0003274971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006367273,"threshold_uncertainty_score":0.9999697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01373762693415224,"score_gpt":0.2715995829239025,"score_spread":0.2578619559897503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}