{"id":"W4387733184","doi":"10.14309/01.ajg.0000954208.38872.e1","title":"S1142 Impact of Guselkumab Therapy on Histologic and Combined Histologic and Endoscopic Outcomes in Patients With Moderately to Severely Active Ulcerative Colitis: Week 12 Results From the Phase 3 QUASAR Induction Study","year":2023,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Medicine; Gastroenterology; Internal medicine; Histology; Histopathology; Randomization; Surgery; Randomized controlled trial; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001766179,0.0004126323,0.001395133,0.000170444,0.0002076357,0.0005651639,0.0002995141,0.0005992774,0.003901355],"category_scores_gemma":[0.0007587321,0.0001587623,0.001285265,0.0002583185,0.0003149988,0.0003500723,0.0002450908,0.001394471,0.000701013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002543632,"about_ca_system_score_gemma":0.0006390592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002742648,"about_ca_topic_score_gemma":0.0008012567,"domain_scores_codex":[0.9995665,0.0002347435,0.00003608366,0.00003525774,0.00006292232,0.0000644156],"domain_scores_gemma":[0.9991429,0.0001883478,0.000284108,0.00006786156,0.00008109891,0.0002356743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7896599,0.01633658,0.02745465,0.0009867777,0.002177975,0.0001465944,0.0001209806,0.0008510906,0.04390191,0.00008952831,0.00256333,0.1157106],"study_design_scores_gemma":[0.1898845,0.6329983,0.1632279,0.0001115903,0.001547802,0.0002400821,0.00007390695,0.001103878,0.007385545,0.0001345415,0.003250876,0.00004103327],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943116,0.002955958,0.0002398633,0.0002694472,0.00005161716,0.0003452152,0.0007266488,0.00003790949,0.001061782],"genre_scores_gemma":[0.9950725,0.0009891943,0.0005791303,0.0004090908,0.0001207878,0.0002940992,0.001326741,0.00001144834,0.001196895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003901355,"threshold_uncertainty_score":0.01305133,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01711703768105277,"score_gpt":0.2787663984198406,"score_spread":0.2616493607387879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}