{"id":"W4387733381","doi":"10.14309/01.ajg.0000953652.76159.59","title":"S1003 Early Real-World Effectiveness and Safety of Upadacitinib in Crohn’s Disease: A Single-Center Study","year":2023,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Medicine; Internal medicine; Adverse effect; Retrospective cohort study; Cohort; Population; Gastroenterology; Combination therapy; Single Center","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003952269,0.0005042679,0.001079303,0.0005659496,0.0004472052,0.001056749,0.0004542518,0.0006286261,0.002180615],"category_scores_gemma":[0.003595285,0.0003213854,0.00122853,0.0009188583,0.0005309706,0.0005976939,0.0005267286,0.0005315236,0.0006039232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005661192,"about_ca_system_score_gemma":0.0009337234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008756066,"about_ca_topic_score_gemma":0.001113965,"domain_scores_codex":[0.9975896,0.001054393,0.0002792094,0.000432647,0.0005015109,0.0001426338],"domain_scores_gemma":[0.9944988,0.001262928,0.002205263,0.0007133297,0.0007433375,0.0005764376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03998411,0.002231499,0.9296433,0.0004453551,0.002912339,0.000437908,0.0001844445,0.0004278331,0.002516913,0.00004299305,0.0006314493,0.02054182],"study_design_scores_gemma":[0.005747652,0.032211,0.9527662,0.0001109287,0.002657281,0.001462756,0.0001778639,0.0009642392,0.002001905,0.00006136309,0.001793226,0.00004556266],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979123,0.0007598658,0.0001675435,0.00003989067,0.0000118745,0.0001112839,0.0006011079,0.000006626491,0.0003894861],"genre_scores_gemma":[0.9981896,0.0002354422,0.000202249,0.00007701414,0.00004991987,0.00007386233,0.001034518,0.000004323096,0.000132949],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003952269,"threshold_uncertainty_score":0.0209018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008688439801941629,"score_gpt":0.2594721578582411,"score_spread":0.2507837180562995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}