{"id":"W4387736757","doi":"10.1093/braincomms/fcad280","title":"Longitudinal clinical, cognitive and biomarker profiles in dominantly inherited versus sporadic early-onset Alzheimer’s disease","year":2023,"lang":"en","type":"article","venue":"Brain Communications","topic":"Genomics and Rare Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; University of California, San Francisco; National Institutes of Health; Genentech; Grifols; H. Lundbeck A/S; Deutsches Zentrum für Neurodegenerative Erkrankungen; National Institute of Neurological Disorders and Stroke; Korea Health Industry Development Institute; Japan Agency for Medical Research and Development; Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University in St. Louis; Bayer Vital; Fondation Brain Canada; Avid Radiopharmaceuticals; Foundation for Barnes-Jewish Hospital; F. Hoffmann-La Roche; Biogen; Eli Lilly and Company; Eisai; National Institute on Aging; Alzheimer's Association; Michael J. Fox Foundation for Parkinson's Research","keywords":"Biomarker; Disease; Early-onset Alzheimer's disease; Alzheimer's disease; Medicine; Internal medicine; Cohort; Age of onset; Cognitive decline; Apolipoprotein E; Dementia; Oncology; Genetics; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003254173,0.0001240228,0.0001329727,0.00009311106,0.0001715757,0.00003660182,0.0003366962,0.00008565277,0.000008190169],"category_scores_gemma":[0.0005404405,0.0001269509,0.00007886672,0.0002603827,0.0004090449,0.000005804096,0.0005038129,0.0001018048,0.00002872284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005223977,"about_ca_system_score_gemma":0.0001315579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000062558,"about_ca_topic_score_gemma":0.0001930479,"domain_scores_codex":[0.998954,0.0002236602,0.0002690931,0.0002974152,0.00006391509,0.0001918965],"domain_scores_gemma":[0.9986231,0.0003095772,0.00007835397,0.0007634646,0.00006645708,0.0001590958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002085209,0.0007459492,0.9585174,0.00002932549,0.0004346857,0.00007892332,0.0002263429,0.00000441022,0.001967363,0.0002718704,0.01761431,0.01802426],"study_design_scores_gemma":[0.001479095,0.00009496236,0.9896089,0.00003660181,0.00006968765,0.00000331974,0.0002395707,0.0002715397,0.00005078761,0.0001084108,0.007858441,0.0001787194],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922126,0.004691589,0.000007141468,0.002091242,0.00007720556,0.000339432,0.0003473675,0.00002340566,0.0002100389],"genre_scores_gemma":[0.9947507,0.002979364,0.0001599855,0.0001776728,0.00003404382,0.0001123672,0.001680919,0.00002093461,0.00008395538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03109151,"threshold_uncertainty_score":0.5176908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1242657510784705,"score_gpt":0.3925658057559401,"score_spread":0.2683000546774695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}