{"id":"W4387736757","doi":"10.1093/braincomms/fcad280","title":"Longitudinal clinical, cognitive and biomarker profiles in dominantly inherited versus sporadic early-onset Alzheimer’s disease","year":2023,"lang":"en","type":"article","venue":"Brain Communications","topic":"Genomics and Rare Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; University of California, San Francisco; National Institutes of Health; Genentech; Grifols; H. Lundbeck A/S; Deutsches Zentrum für Neurodegenerative Erkrankungen; National Institute of Neurological Disorders and Stroke; Korea Health Industry Development Institute; Japan Agency for Medical Research and Development; Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University in St. Louis; Bayer Vital; Fondation Brain Canada; Avid Radiopharmaceuticals; Foundation for Barnes-Jewish Hospital; F. Hoffmann-La Roche; Biogen; Eli Lilly and Company; Eisai; National Institute on Aging; Alzheimer's Association; Michael J. Fox Foundation for Parkinson's Research","keywords":"Biomarker; Disease; Early-onset Alzheimer's disease; Alzheimer's disease; Medicine; Internal medicine; Cohort; Age of onset; Cognitive decline; Apolipoprotein E; Dementia; Oncology; Genetics; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001755409,0.0003038711,0.0004275112,0.000897755,0.0005899874,0.0006376061,0.0003435515,0.0004820936,0.0007160699],"category_scores_gemma":[0.00323442,0.0002322663,0.0003687576,0.0008195997,0.0002088506,0.0005468954,0.000516196,0.000624406,0.0001634008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000289776,"about_ca_system_score_gemma":0.000266801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005209586,"about_ca_topic_score_gemma":0.00540838,"domain_scores_codex":[0.9994196,0.0001878067,0.00005899887,0.0001319088,0.0001040684,0.00009775852],"domain_scores_gemma":[0.9979677,0.0003680356,0.0007604622,0.0001461927,0.0004464653,0.0003111826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000299372,0.00006008747,0.9982461,0.000004712123,0.00005386868,0.00006479469,0.0001233975,0.00001941354,0.0002792399,0.00001091667,0.00004915439,0.000788959],"study_design_scores_gemma":[0.000006158819,0.0001364787,0.999182,0.000003854576,0.00002087736,0.0002023711,0.0001686196,0.0001214709,0.0000603354,0.0000298455,0.0000650265,0.000002821652],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996136,0.0001143893,0.00003339452,0.00001167447,0.000002105279,0.00000293124,0.000125525,9.940169e-7,0.00009532648],"genre_scores_gemma":[0.9995165,0.00003502404,0.000044834,0.00001023904,0.000003781903,0.000004682787,0.0003117253,8.311171e-7,0.0000724918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005209586,"threshold_uncertainty_score":0.01035857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1242657510784705,"score_gpt":0.3925658057559401,"score_spread":0.2683000546774695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}