{"id":"W4387737168","doi":"10.1136/bjo-2023-323640","title":"<i>KCNV2</i>-associated retinopathy: genotype–phenotype correlations –<i>KCNV2</i>study group report 3","year":2023,"lang":"en","type":"article","venue":"British Journal of Ophthalmology","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Janssen Pharmaceuticals; National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology; National Eye Institute; Moorfields Eye Charity; Moorfields Eye Hospital NHS Foundation Trust; Instituto de Salud Carlos III; Retina UK; Wellcome Trust; Active Biotech; Biogen; Ministry of Health, Labour and Welfare; Deutsche Forschungsgemeinschaft; Research to Prevent Blindness; Santen; National Institute for Health and Care Research; National Institutes of Health; Foundation Fighting Blindness; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Spark Therapeutics; Novartis","keywords":"Medicine; Ophthalmology; Electroretinography; Visual acuity; Retinal; Erg","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001178011,0.0001891981,0.000360704,0.0001490241,0.000211728,0.00005526527,0.0003304998,0.0002381707,0.0001420714],"category_scores_gemma":[0.001124854,0.0002233727,0.0001871401,0.0004478807,0.0001005879,0.00001464412,0.0001561791,0.0003021901,0.00005436492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002872383,"about_ca_system_score_gemma":0.0001877318,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000731176,"about_ca_topic_score_gemma":0.00002376576,"domain_scores_codex":[0.9978501,0.0002613044,0.0008154912,0.0003473304,0.0003218431,0.0004039346],"domain_scores_gemma":[0.998577,0.00005234292,0.0005886236,0.000231268,0.0004096855,0.0001410611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006850782,0.00140598,0.8265594,0.00002763268,0.0007316569,0.08755578,0.0003446253,0.0003312139,0.02378836,0.00004368561,0.05430888,0.004217678],"study_design_scores_gemma":[0.002416752,0.002108748,0.8971015,0.00005367759,0.0000990046,0.09264315,0.0004254552,0.00001546176,0.0003079078,0.0005595035,0.003874448,0.0003943541],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990665,0.000754864,0.00007959534,0.0001068847,0.0009853871,0.0002355794,0.000009507406,0.00002405406,0.007139198],"genre_scores_gemma":[0.9949607,0.0002097464,0.0002008111,0.00006031193,0.0002392623,0.00001167443,0.0002608185,0.00004302712,0.00401366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07054211,"threshold_uncertainty_score":0.9108876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01422125344359373,"score_gpt":0.2643689020181297,"score_spread":0.250147648574536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}