{"id":"W4387747059","doi":"10.1016/j.omtm.2023.101139","title":"Lipid nanoparticles outperform electroporation in mRNA-based CAR T cell engineering","year":2023,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"Precision Nanosystems (Canada)","funders":"Bundesministerium für Bildung und Forschung","keywords":"Electroporation; Chimeric antigen receptor; In vitro; In vivo; Messenger RNA; Cell; Ex vivo; T cell; Cell biology; Chemistry; Biology; Immunology; Immune system; Biotechnology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002046556,0.00030652,0.0001935866,0.0001533686,0.00009341982,0.0004002368,0.0001106712,0.0003509898,0.001084261],"category_scores_gemma":[0.000385448,0.000105477,0.0001738033,0.00009560736,0.0002123607,0.0003532252,0.0002452907,0.0003254386,0.0003861777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000270375,"about_ca_system_score_gemma":0.0002198708,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005298458,"about_ca_topic_score_gemma":0.0006338104,"domain_scores_codex":[0.9998354,0.00004060162,0.00001440243,0.00004597388,0.00003658314,0.00002706862],"domain_scores_gemma":[0.9998564,0.00005679075,0.00003454099,0.000009699199,0.00003020579,0.0000124237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001428212,0.00002272311,0.0001123405,0.00007463221,0.000004905867,0.00004895634,0.00002467085,0.0003411951,0.9933977,0.0002187402,0.00005592889,0.005555433],"study_design_scores_gemma":[0.000007974358,0.0002764166,0.0003785794,0.000005341939,0.00002242063,0.00008587317,0.00001284457,0.001346561,0.9956145,0.00006347962,0.002182142,0.000003769328],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9660003,0.004413262,0.02302635,0.0002842429,0.0000986236,0.00008244297,0.000135339,0.0002425889,0.005716908],"genre_scores_gemma":[0.9879212,0.001428145,0.006321609,0.00007117358,0.00001672129,0.00003622424,0.0001230684,0.00004074584,0.00404101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001084261,"threshold_uncertainty_score":0.003627241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09062217181834831,"score_gpt":0.4393684752559198,"score_spread":0.3487463034375715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}