{"id":"W4387747110","doi":"10.1016/j.antiviral.2023.105736","title":"ASK1 inhibitors are potential pan-antiviral drugs, which dampen replication of diverse viruses including SARS-CoV2","year":2023,"lang":"en","type":"article","venue":"Antiviral Research","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canada Foundation for Innovation","keywords":"Biology; Virology; ASK1; Virus; Viral replication; Protein kinase R; Kinase; Vaccinia; Activator (genetics); Protein kinase A; Interferon; Cell biology; Mitogen-activated protein kinase kinase; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001954276,0.0004195401,0.0004031682,0.0003624835,0.0001637071,0.0002483158,0.0001517445,0.0002236088,0.002062859],"category_scores_gemma":[0.0000863191,0.0000717451,0.0002661671,0.0001745382,0.0001477938,0.0002409312,0.0001638459,0.0006888969,0.0003913277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001677012,"about_ca_system_score_gemma":0.0001597581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001185691,"about_ca_topic_score_gemma":0.0006340711,"domain_scores_codex":[0.9999205,0.00001984213,0.000008685979,0.00001520229,0.0000179773,0.00001771907],"domain_scores_gemma":[0.999953,0.000007816312,0.00001473033,0.000004113482,0.000008537325,0.00001166679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001558856,0.0007765067,0.001189785,0.001004479,0.00009708408,0.0002329319,0.00005325712,0.0005516043,0.890115,0.0008684044,0.001538374,0.1020136],"study_design_scores_gemma":[0.0004143881,0.00986051,0.01043776,0.00009042211,0.0001572743,0.001442066,0.00007750479,0.001603026,0.9251294,0.0005517173,0.05020799,0.00002799942],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.880336,0.09893787,0.005897868,0.0008168113,0.0003299753,0.0003103677,0.001218369,0.0003604457,0.0117923],"genre_scores_gemma":[0.9688742,0.02062652,0.002826293,0.0002990784,0.00006836744,0.0001326273,0.001263501,0.00001913555,0.005890197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002062859,"threshold_uncertainty_score":0.006900966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1199823769083032,"score_gpt":0.4104682033929928,"score_spread":0.2904858264846897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}