{"id":"W4387749799","doi":"10.14309/01.ajg.0000954916.11720.6e","title":"S1319 Seladelpar Treatment Resulted in Correlated Decreases in Serum IL-31 and Pruritus in Patients With Primary Biliary Cholangitis (PBC): Post-Hoc Results from the Phase 3 Randomized, Placebo-Controlled ENHANCE Study","year":2023,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Liver Centre","funders":"","keywords":"Medicine; Internal medicine; Gastroenterology; Placebo; Quality of life (healthcare); Randomized controlled trial; Cytokine; Cholestasis; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001215184,0.0005640672,0.001884209,0.0001964042,0.0001604185,0.0004707414,0.0002994721,0.0006377238,0.004604385],"category_scores_gemma":[0.001011425,0.0003672804,0.001186938,0.0001956831,0.0004992352,0.0003846265,0.0002804646,0.001107204,0.0004766092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001996092,"about_ca_system_score_gemma":0.0004770115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000264155,"about_ca_topic_score_gemma":0.0008241091,"domain_scores_codex":[0.9995371,0.0002802456,0.00003897525,0.00005096534,0.00004415902,0.00004849642],"domain_scores_gemma":[0.9991626,0.0003086534,0.0002445944,0.00006799648,0.00005257744,0.0001635746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9185914,0.01088945,0.003931306,0.0009180199,0.001817041,0.00009103082,0.00007876551,0.0003908373,0.03550491,0.00005671282,0.0006824526,0.0270481],"study_design_scores_gemma":[0.3556743,0.5943572,0.03902834,0.00005299991,0.001815318,0.0001931894,0.00006493673,0.0004863255,0.007018422,0.00005943106,0.001223284,0.0000262109],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970875,0.001445418,0.0001265127,0.0001320488,0.00003656177,0.0003443383,0.000292953,0.00003163475,0.0005028672],"genre_scores_gemma":[0.9971644,0.0006487171,0.000442498,0.0002110852,0.00009300604,0.000306057,0.0004002226,0.000007308044,0.0007267446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004604385,"threshold_uncertainty_score":0.01540327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004181328322167908,"score_gpt":0.2249474694014283,"score_spread":0.2207661410792604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}