{"id":"W4387750852","doi":"10.14309/01.ajg.0000953008.12749.fc","title":"S842 Pharmacokinetics, Exposure-Response Relationships, and Immunogenicity in Crohn’s Disease Patients With Ustekinumab Secondary Loss of Response Following Ustekinumab IV Re-Induction: Week 16 Results From the POWER Study","year":2023,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Medicine; Ustekinumab; Gastroenterology; Internal medicine; Pharmacokinetics; Dosing; Immunogenicity; Immunology; Antibody; Disease; Adalimumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00409307,0.0004327193,0.001031689,0.0002944348,0.0001251893,0.0005959563,0.00023772,0.0004137201,0.001905692],"category_scores_gemma":[0.004136627,0.0002462619,0.001037933,0.0003055414,0.0004227728,0.0008351476,0.0003597404,0.0008196711,0.0005726309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00033805,"about_ca_system_score_gemma":0.0003073367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008637436,"about_ca_topic_score_gemma":0.00009555641,"domain_scores_codex":[0.9986368,0.0008470474,0.00008298734,0.0001164453,0.0002206827,0.00009605241],"domain_scores_gemma":[0.9971319,0.001099506,0.0009983958,0.0002900617,0.0001923514,0.0002877476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.4524905,0.01696154,0.2805329,0.0008298566,0.002326342,0.000671958,0.0007169503,0.003742877,0.06211089,0.0002440434,0.001939191,0.177433],"study_design_scores_gemma":[0.03736125,0.5870182,0.3480192,0.00005240981,0.00116209,0.001238478,0.0001439906,0.005703281,0.0152716,0.0004364474,0.003546716,0.00004638331],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988457,0.0002768151,0.0003036617,0.00004465593,0.000007233722,0.00008747668,0.00009225484,0.00001293277,0.0003292683],"genre_scores_gemma":[0.998844,0.00008447492,0.0002625704,0.00006763886,0.0000311992,0.00008775963,0.0002427877,0.00000655343,0.0003729805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00409307,"threshold_uncertainty_score":0.02164644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01007815849905093,"score_gpt":0.2416192359297298,"score_spread":0.2315410774306788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}