{"id":"W4387750879","doi":"10.14309/01.ajg.0000954300.04358.bb","title":"S1165 Efficacy and Safety of Etrasimod in Patients With Moderate to Severe Isolated Proctitis Relative to Those With More Extensive Colitis: Results From the Phase 3 ELEVATE UC 52 and ELEVATE UC 12 Trials","year":2023,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pfizer (Canada); Western University","funders":"","keywords":"Medicine; Proctitis; Internal medicine; Ulcerative colitis; Pancolitis; Colitis; Gastroenterology; Placebo; Population; Clinical trial; Clinical endpoint; Colonoscopy; Colorectal cancer; Pathology; Disease; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002402059,0.0007239742,0.002371647,0.0004073764,0.0002708089,0.001141809,0.0003986298,0.001035732,0.009449144],"category_scores_gemma":[0.002552622,0.0002949149,0.003222327,0.0006427658,0.0003747694,0.0006984171,0.0003197579,0.002114427,0.001056072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003657,"about_ca_system_score_gemma":0.0006546533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003225706,"about_ca_topic_score_gemma":0.001250742,"domain_scores_codex":[0.9988882,0.0006266487,0.0001768215,0.0001233069,0.0001190463,0.00006597154],"domain_scores_gemma":[0.9977349,0.000735183,0.0008914195,0.0001068422,0.0001962388,0.0003353541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.824037,0.003008614,0.007366286,0.008128699,0.009319511,0.0001195136,0.00008415606,0.0006534674,0.009483122,0.0002649024,0.005453664,0.132081],"study_design_scores_gemma":[0.6932141,0.2101848,0.06537639,0.001282996,0.01324861,0.0004992888,0.0001151215,0.001407075,0.003447812,0.00062728,0.01050117,0.00009544272],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8691935,0.1042991,0.001202427,0.002413658,0.00113811,0.002057743,0.006881912,0.0001914712,0.01262204],"genre_scores_gemma":[0.9721885,0.01667212,0.001048013,0.001825908,0.0008003553,0.0007326756,0.004250667,0.0000220926,0.002459741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009449144,"threshold_uncertainty_score":0.03161055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01052931952608502,"score_gpt":0.2662534778898437,"score_spread":0.2557241583637587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}