{"id":"W4387750964","doi":"10.14309/01.ajg.0000953268.71939.f4","title":"S907 Guselkumab Improves Abdominal Pain and Bowel Urgency Symptoms in Patients With Moderately to Severely Active Ulcerative Colitis: Results From the Phase 3 QUASAR Induction Study","year":2023,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Pharmacological Effects of Natural Compounds","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; Western University","funders":"","keywords":"Medicine; Ulcerative colitis; Abdominal pain; Abdomen; Internal medicine; Inflammatory bowel disease; Placebo; Gastroenterology; Randomized controlled trial; Surgery; Physical therapy; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002770599,0.0003096923,0.0006646722,0.000212172,0.0002903736,0.00003469879,0.0005630888,0.00007734972,0.00002329031],"category_scores_gemma":[0.000420402,0.000171872,0.0000774013,0.0005028997,0.0006429746,0.0002129855,0.0001828097,0.001609861,0.00000821594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001561811,"about_ca_system_score_gemma":0.0000663469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001331409,"about_ca_topic_score_gemma":0.000217086,"domain_scores_codex":[0.9922655,0.005811412,0.0006685246,0.0003605885,0.0003040203,0.0005899909],"domain_scores_gemma":[0.9961008,0.002369016,0.0008335147,0.0001911063,0.0002561707,0.000249339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8917338,0.001998526,0.03599368,0.00000377538,0.001298166,0.0001901894,0.008047867,0.001648709,0.001450357,0.00000340936,0.002115269,0.05551628],"study_design_scores_gemma":[0.01529969,0.06033663,0.9186053,0.00001939358,0.0002294647,0.00003735542,0.003491119,0.001415839,0.0001563611,0.0001255685,0.0001458136,0.0001374877],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930614,0.00001780332,0.00006009328,0.005158597,0.0004389465,0.001070874,0.0001559246,0.00002667597,0.00000970664],"genre_scores_gemma":[0.994473,0.00002439504,0.00007342325,0.00511268,0.0002173117,0.00005182419,0.00001527267,0.00002133253,0.00001072556],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8826116,"threshold_uncertainty_score":0.7008739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03892961343218774,"score_gpt":0.3745639731041113,"score_spread":0.3356343596719236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}