{"id":"W4387751058","doi":"10.14309/01.ajg.0000953712.25499.35","title":"S1018 Early Disease Clearance With Etrasimod and Correlation With Week 52 Outcomes and Biomarkers: A Post Hoc Analysis of the Phase 3 ELEVATE UC Trials","year":2023,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Medicine; Post-hoc analysis; Internal medicine; Clinical endpoint; Gastroenterology; Placebo; Post hoc; Ulcerative colitis; Clinical trial; Surrogate endpoint; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01931519,0.001556314,0.00299502,0.0004402912,0.0004272713,0.001368505,0.0007940128,0.0009777057,0.00472886],"category_scores_gemma":[0.01144123,0.000398162,0.005030984,0.0006582045,0.0008228284,0.001028414,0.0008967069,0.002115154,0.0007759872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005336984,"about_ca_system_score_gemma":0.001441097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005202134,"about_ca_topic_score_gemma":0.001091452,"domain_scores_codex":[0.9888846,0.008271434,0.0005963731,0.0008794665,0.0007560151,0.0006121458],"domain_scores_gemma":[0.9839978,0.009047638,0.003065246,0.001866278,0.001082551,0.000940531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9485607,0.002959978,0.02101826,0.0006254705,0.009920632,0.00009852178,0.0001213166,0.001206979,0.00354686,0.00009287971,0.002179273,0.009669068],"study_design_scores_gemma":[0.2508145,0.4435242,0.2631262,0.000189806,0.02187094,0.0003026636,0.0002798252,0.007260958,0.005546949,0.0006054358,0.006308559,0.0001701123],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904203,0.001905545,0.0009378088,0.0002610816,0.0001325909,0.001523843,0.003073952,0.00006979243,0.001675162],"genre_scores_gemma":[0.9902881,0.0003312796,0.00112954,0.00034455,0.0001496099,0.002531823,0.003269243,0.00005079649,0.001905021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01931519,"threshold_uncertainty_score":0.1021497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009305943313724618,"score_gpt":0.263384668401277,"score_spread":0.2540787250875524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}