{"id":"W4387751088","doi":"10.14309/01.ajg.0000953568.00881.40","title":"S982 Association of Histologic-Endoscopic Response and Long-Term Clinical Outcomes: Results From Phase 2 Mirikizumab Trial in Patients With Moderately-to-Severely Active Crohn’s Disease","year":2023,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Medicine; Crohn's disease; Internal medicine; Gastroenterology; Randomized controlled trial; Clinical endpoint; Clinical disease; Endoscopy; Disease; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003866352,0.0005948401,0.001298488,0.0001921296,0.0002523599,0.0007008978,0.0004039024,0.0007634375,0.002389725],"category_scores_gemma":[0.001876351,0.0002863991,0.001292249,0.0002167717,0.0004714999,0.0006398143,0.0003381108,0.001507525,0.0004094373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002598312,"about_ca_system_score_gemma":0.0004985846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001237138,"about_ca_topic_score_gemma":0.0003287403,"domain_scores_codex":[0.9989834,0.0006441773,0.00008417803,0.0001107211,0.00009835629,0.00007909522],"domain_scores_gemma":[0.9981812,0.0005302738,0.0005468775,0.0001604326,0.000135772,0.000445407],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8966691,0.008097988,0.03221171,0.0005635274,0.001513116,0.00008629647,0.0001165444,0.0005521945,0.01712527,0.00008141218,0.001108207,0.04187456],"study_design_scores_gemma":[0.3582098,0.4451924,0.1838315,0.0001108252,0.00210651,0.0003189835,0.0000817492,0.001465776,0.004955598,0.0002542809,0.003405299,0.00006733509],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960954,0.001907589,0.0002452326,0.0002741796,0.000065575,0.0003304387,0.0004390944,0.00001374824,0.000628904],"genre_scores_gemma":[0.9950522,0.0006857757,0.0007231536,0.0003855668,0.0002529566,0.0005554906,0.001413247,0.000008714449,0.0009228165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003866352,"threshold_uncertainty_score":0.02044749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0140845062392508,"score_gpt":0.3026737381106162,"score_spread":0.2885892318713654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}