{"id":"W4387751113","doi":"10.14309/01.ajg.0000953932.96791.1d","title":"S1073 Clinical Outcomes and Biomarker Normalization Response at Week 16 in Patients With Inadequate Response or Intolerance to Prior Biologics in the POWER Trial","year":2023,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Medicine; Clinical endpoint; Placebo; Internal medicine; Calprotectin; Gastroenterology; Randomization; Randomized controlled trial; Clinical trial; Biomarker; Surgery; Disease; Inflammatory bowel disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004977816,0.0009069428,0.002098167,0.0002555718,0.0002514998,0.001109848,0.0004521128,0.0009400692,0.007332664],"category_scores_gemma":[0.004385267,0.0002925185,0.002193543,0.0004473798,0.0006767384,0.0009726908,0.0004582445,0.001700339,0.001008379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003215309,"about_ca_system_score_gemma":0.0007083612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001545631,"about_ca_topic_score_gemma":0.000313554,"domain_scores_codex":[0.9983767,0.001076658,0.0001312391,0.0001552631,0.0001162036,0.000143868],"domain_scores_gemma":[0.9978077,0.0009011762,0.0006436271,0.0002043673,0.0001469705,0.0002961254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9354129,0.001672243,0.006902391,0.001616476,0.003340436,0.0001294558,0.00008840352,0.0006050178,0.001968082,0.0002881988,0.003462472,0.04451396],"study_design_scores_gemma":[0.7983102,0.1518799,0.03292306,0.0004816919,0.005153773,0.0003533678,0.00008011395,0.001252572,0.001333854,0.001319654,0.00687313,0.00003869007],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9716132,0.01400729,0.001128872,0.001957291,0.0005099247,0.002267082,0.001851794,0.0001626435,0.006501907],"genre_scores_gemma":[0.9910211,0.00190048,0.0007014822,0.0008016471,0.0005541347,0.001788578,0.001318373,0.00002836889,0.001885881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007332664,"threshold_uncertainty_score":0.02632558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01796018785643611,"score_gpt":0.3010561431534031,"score_spread":0.283095955296967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}