{"id":"W4387751266","doi":"10.14309/01.ajg.0000953028.28572.20","title":"S847 Efficacy of Guselkumab in Patients With Moderately to Severely Active Crohn’s Disease Not in Clinical Response at Week 12: Results From the GALAXI 1 Study","year":2023,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Placebo; Internal medicine; Population; Clinical endpoint; Clinical trial; Gastroenterology; Randomized controlled trial; Surgery; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002129742,0.0006341007,0.001914983,0.0002077375,0.0001911009,0.0006451243,0.0004280962,0.0008538695,0.00336999],"category_scores_gemma":[0.001284481,0.0002591054,0.001977899,0.0003041095,0.0004814638,0.0004890197,0.000340443,0.001463923,0.0007228395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004444352,"about_ca_system_score_gemma":0.0005657174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003554307,"about_ca_topic_score_gemma":0.000769169,"domain_scores_codex":[0.999245,0.0004754091,0.0000640624,0.00007155679,0.00007529393,0.00006869628],"domain_scores_gemma":[0.9992694,0.0002130439,0.0001953778,0.00006178681,0.00005965008,0.0002006759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8574359,0.008981112,0.01588192,0.001860626,0.002961189,0.0001855772,0.0001741373,0.0005595515,0.01239272,0.0001523155,0.002744865,0.09667012],"study_design_scores_gemma":[0.5122101,0.4087271,0.06805,0.0002321613,0.00268219,0.000249652,0.0000795462,0.0005140649,0.001597587,0.0002032016,0.005410926,0.00004351786],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985762,0.009668937,0.0002292199,0.0007245654,0.0001618169,0.000588364,0.0009049345,0.00003785417,0.001922387],"genre_scores_gemma":[0.9906205,0.003767225,0.000539985,0.001164091,0.0003104669,0.000558345,0.001692235,0.00001728906,0.001329773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00336999,"threshold_uncertainty_score":0.01127374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01639617696841488,"score_gpt":0.278105371423593,"score_spread":0.2617091944551781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}