{"id":"W4387751374","doi":"10.14309/01.ajg.0000953020.05891.05","title":"S845 Risankizumab Induction Therapy in Patients With Moderately to Severely Active Ulcerative Colitis: Efficacy and Safety in the Randomized Phase 3 INSPIRE Study","year":2023,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Ulcerative colitis; Internal medicine; Clinical endpoint; Gastroenterology; Placebo; Randomized controlled trial; Phases of clinical research; Clinical trial; Surgery; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004051045,0.0008903502,0.002106603,0.0001919636,0.0003336059,0.0007787799,0.0007333789,0.001033996,0.003974619],"category_scores_gemma":[0.001740523,0.0003917039,0.002177896,0.0002688179,0.0005348414,0.0005330701,0.0004274941,0.002266801,0.0006592407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005394966,"about_ca_system_score_gemma":0.0012017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006743771,"about_ca_topic_score_gemma":0.002435625,"domain_scores_codex":[0.9989352,0.0007131816,0.00006454562,0.00009539434,0.0001004305,0.00009127679],"domain_scores_gemma":[0.9990599,0.0002070153,0.0002729672,0.0001008954,0.00009892394,0.0002602995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.947592,0.005834827,0.004365997,0.0008468328,0.001854773,0.00007793815,0.00009017665,0.0004005753,0.006221097,0.0001483439,0.003053753,0.02951378],"study_design_scores_gemma":[0.8791581,0.09930959,0.01647115,0.00007818811,0.001216466,0.0001261474,0.00002303552,0.0004905509,0.0007233225,0.0001506302,0.002229516,0.00002330945],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9792933,0.006839618,0.0009005584,0.001087917,0.0002284736,0.004889044,0.002629247,0.0001413008,0.003990562],"genre_scores_gemma":[0.9814207,0.002695458,0.002661083,0.002033462,0.0003286737,0.00461997,0.003843646,0.00002915343,0.002367793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004051045,"threshold_uncertainty_score":0.02142423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008203309286437283,"score_gpt":0.2651989839612389,"score_spread":0.2569956746748017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}