{"id":"W4387751399","doi":"10.14309/01.ajg.0000953892.59221.8e","title":"S1063 Improvement in Inflammatory Biomarker Levels Through Week 12 in Moderately to Severely Active Ulcerative Colitis Patients Treated With Guselkumab: Results From the Phase 3 QUASAR Induction Study","year":2023,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Medicine; Gastroenterology; Calprotectin; Internal medicine; Ulcerative colitis; C-reactive protein; Feces; Placebo; Biomarker; Inflammatory bowel disease; Inflammation; Pathology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009844342,0.0004804726,0.00141638,0.0001631614,0.0002064585,0.000508772,0.0003198344,0.0005884683,0.001996305],"category_scores_gemma":[0.0005326061,0.0002180698,0.001115055,0.0002395861,0.0003135426,0.0003542962,0.0002316323,0.001338289,0.0005047033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002493062,"about_ca_system_score_gemma":0.0004820479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003483005,"about_ca_topic_score_gemma":0.0007257308,"domain_scores_codex":[0.9997059,0.0001375353,0.00002687783,0.00003583887,0.00003824426,0.00005551648],"domain_scores_gemma":[0.9995902,0.00006640732,0.0001075601,0.00003058379,0.00003488278,0.000170333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.7064764,0.03179136,0.02683259,0.0008782716,0.002059494,0.0002153178,0.0001909346,0.001053738,0.07728101,0.00009773269,0.002539972,0.1505832],"study_design_scores_gemma":[0.1850444,0.6726205,0.1337764,0.00006613252,0.0008801949,0.0002762742,0.00008391053,0.001147216,0.004101022,0.00009049783,0.00187904,0.00003430723],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975923,0.001275188,0.0001432106,0.0001287071,0.00003091393,0.0001541311,0.0002829522,0.00002992325,0.0003626381],"genre_scores_gemma":[0.9970137,0.0006511543,0.000395787,0.000351628,0.00005339205,0.0001620867,0.0007636676,0.00000827755,0.000600351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001996305,"threshold_uncertainty_score":0.006678343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02274623337582988,"score_gpt":0.2772778620362301,"score_spread":0.2545316286604002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}