{"id":"W4387751565","doi":"10.14309/01.ajg.0000954412.44947.f2","title":"S1193 Safety of Upadacitinib in IBD: Pooled Analysis of Phase 3 Maintenance Studies, U-ACHIEVE and U-ENDURE, In Patients With Moderately to Severely Active Ulcerative Colitis or Crohn’s Disease","year":2023,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Ulcerative colitis; Internal medicine; Discontinuation; Adverse effect; Gastroenterology; Placebo; Population; Maintenance therapy; Randomization; Crohn's disease; Surgery; Clinical trial; Disease; Chemotherapy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0252117,0.001279384,0.004662075,0.001888656,0.0002908591,0.001832695,0.000622685,0.001204671,0.003334203],"category_scores_gemma":[0.02171885,0.0005599716,0.01739535,0.00244412,0.0004317649,0.0007485381,0.0008886576,0.0009107327,0.0004278626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005939476,"about_ca_system_score_gemma":0.001155665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006861845,"about_ca_topic_score_gemma":0.001320672,"domain_scores_codex":[0.9812324,0.01075184,0.003797797,0.001433128,0.002475275,0.0003095354],"domain_scores_gemma":[0.9812133,0.009465544,0.006299023,0.001319139,0.001420842,0.000282153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.1542403,0.0002725431,0.04670137,0.03428255,0.6743177,0.0002407911,0.0001605193,0.002578221,0.004806183,0.0002661556,0.005195947,0.07693768],"study_design_scores_gemma":[0.03974873,0.01932235,0.2017597,0.003551495,0.7077635,0.001051147,0.0001440522,0.003175966,0.00448931,0.001112099,0.01770858,0.0001731032],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5430862,0.3969973,0.01049513,0.001461263,0.0008217912,0.003706255,0.03516223,0.0005644383,0.007705321],"genre_scores_gemma":[0.9650941,0.0181758,0.00265623,0.0008099597,0.0004209452,0.001420452,0.01030744,0.00007783087,0.001037166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0252117,"threshold_uncertainty_score":0.1333339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009998056375952455,"score_gpt":0.2756435644680574,"score_spread":0.2656455080921049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}