{"id":"W4387751628","doi":"10.14309/01.ajg.0000954212.50962.cc","title":"S1143 The Anti-TL1A Antibody PRA023 Demonstrated Proof-of-Concept in Crohn’s Disease: Phase 2a APOLLO-CD Study Results","year":2023,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Medicine; Placebo; Crohn's disease; Internal medicine; Clinical endpoint; Gastroenterology; Disease; Clinical trial; Surrogate endpoint; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003289823,0.0007385661,0.0009829679,0.000221069,0.0002868169,0.00102555,0.0005680453,0.001420746,0.005856453],"category_scores_gemma":[0.001228234,0.0002492263,0.001061099,0.000204976,0.0003797761,0.0004090405,0.0002797169,0.00239901,0.001538382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005118674,"about_ca_system_score_gemma":0.001322085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005362183,"about_ca_topic_score_gemma":0.0009723133,"domain_scores_codex":[0.9994044,0.0002918149,0.00003153126,0.00006560006,0.0001182172,0.00008843572],"domain_scores_gemma":[0.9991317,0.0002077378,0.0001548923,0.00006535402,0.0001469516,0.0002933669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.398491,0.04933146,0.01061974,0.003890658,0.002822738,0.0009970904,0.0003918221,0.002937576,0.1615197,0.001321554,0.05263733,0.3150393],"study_design_scores_gemma":[0.4197217,0.4662604,0.02447187,0.0003408064,0.001381667,0.001587917,0.00007056951,0.00324792,0.02629189,0.0005607728,0.05600705,0.00005743594],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9495962,0.01625277,0.004019972,0.003990184,0.000721866,0.004561459,0.006896899,0.0004900225,0.01347071],"genre_scores_gemma":[0.9608544,0.005327628,0.005643776,0.004807876,0.0006219152,0.002980297,0.008612122,0.000122515,0.01102942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005856453,"threshold_uncertainty_score":0.01959181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0109748491617397,"score_gpt":0.301651443168716,"score_spread":0.2906765940069763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}