{"id":"W4387761620","doi":"10.1016/s1474-4422(23)00374-5","title":"α-synuclein seed amplification in Parkinson‘s disease","year":2023,"lang":"en","type":"letter","venue":"The Lancet Neurology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Rehabilitation Institute; University of Toronto; University Health Network; Ottawa Hospital; Toronto Western Hospital; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Parkinson Canada; Weston Brain Institute; Ontario Brain Institute; Michael J. Fox Foundation for Parkinson's Research","keywords":"Parkinson's disease; Disease; Medicine; Alpha-synuclein; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001437666,0.0007943625,0.001404871,0.0009020173,0.002698253,0.002060853,0.001135927,0.04678993,0.004250884],"category_scores_gemma":[0.01472106,0.0006556854,0.001178762,0.0007382969,0.00254847,0.002408116,0.001048503,0.02267497,0.003491266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003461844,"about_ca_system_score_gemma":0.002157392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004586885,"about_ca_topic_score_gemma":0.00598208,"domain_scores_codex":[0.9988814,0.0003008924,0.000183465,0.0001674573,0.0003026841,0.0001640843],"domain_scores_gemma":[0.9946771,0.003519369,0.0003992695,0.000166167,0.0006460365,0.0005921725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000213724,0.00004618277,0.00142404,0.0001461611,0.00006372919,0.02279724,0.0001961232,0.0001243786,0.0006430554,0.00484892,0.9452183,0.02427812],"study_design_scores_gemma":[0.00134168,0.000375796,0.006009666,0.001176459,0.0003654024,0.05355057,0.0007204938,0.002602008,0.001564597,0.06042557,0.8716967,0.0001711279],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.001536808,0.005088199,0.0001374376,0.9676407,0.02036763,0.0000122233,0.00006617206,0.00003103117,0.00511978],"genre_scores_gemma":[0.02619166,0.004821433,0.0003391076,0.818976,0.1397618,0.00004720489,0.0000509691,0.00004580642,0.009766065],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.04678993,"threshold_uncertainty_score":0.02511752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05045288915826302,"score_gpt":0.2872705145484891,"score_spread":0.2368176253902261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}