{"id":"W4387767163","doi":"10.1016/j.scr.2023.103234","title":"Generation of induced pluripotent stem cell lines from pediatric patients with congenital myotonic dystrophy (CBRCULi012-A and CBRCULi013-A) and age-matched controls (CBRCULi010-A and CBRCULi011-A)","year":2023,"lang":"en","type":"article","venue":"Stem Cell Research","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut Universitaire en Santé Mentale de Québec","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Fondation CHU de Québec; French Muscular Dystrophy Association; Advanced Foods and Materials Canada; U.S. Department of Defense","keywords":"Myotonic dystrophy; Biology; Induced pluripotent stem cell; Trinucleotide repeat expansion; Genetics; Myotonia; Allele; Gene; Cell biology; Molecular biology; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002881536,0.0002320848,0.0002686969,0.0004492188,0.0002241766,0.0002314994,0.0002397584,0.0003608633,0.002926835],"category_scores_gemma":[0.0003956108,0.0001136084,0.0002567733,0.0003352913,0.0001857592,0.0001030132,0.0002507319,0.0004522924,0.0007097945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001100578,"about_ca_system_score_gemma":0.0001821402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000410865,"about_ca_topic_score_gemma":0.0006371611,"domain_scores_codex":[0.9998232,0.00001991538,0.00005079842,0.00004136047,0.00004660312,0.00001826493],"domain_scores_gemma":[0.9998198,0.00004755172,0.00003265936,0.00003743111,0.00002972829,0.00003289084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004538388,0.0002749754,0.01596598,0.0001962155,0.00005814351,0.003440644,0.0006098367,0.0003635637,0.9538771,0.001182406,0.0007242184,0.02285316],"study_design_scores_gemma":[0.0004922699,0.004153629,0.1487363,0.0001470137,0.0003164564,0.04384411,0.001077858,0.003520743,0.7489617,0.0005745734,0.04810376,0.00007160183],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9817737,0.000988677,0.009001685,0.0001113629,0.000109664,0.0006478735,0.003729385,0.0001055497,0.003532026],"genre_scores_gemma":[0.9706184,0.001294715,0.01343184,0.0001500686,0.00004136161,0.0006535252,0.0110261,0.00003702571,0.002747046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002926835,"threshold_uncertainty_score":0.009791195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09546202840985792,"score_gpt":0.298171862985259,"score_spread":0.2027098345754011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}