{"id":"W4387769798","doi":"10.1021/acs.biochem.3c00337","title":"High-Affinity Fluorogenic Substrate for Tissue Transglutaminase Reveals Enzymatic Hysteresis","year":2023,"lang":"en","type":"article","venue":"Biochemistry","topic":"Blood properties and coagulation","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Tissue transglutaminase; Chemistry; Enzyme; Substrate (aquarium); Biochemistry; GTP'; Isozyme; Allosteric regulation; Biophysics; Combinatorial chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001627595,0.0001378491,0.0002386586,0.00003015532,0.00007591167,0.00001844647,0.00007835815,0.0001401492,0.0001332826],"category_scores_gemma":[0.00007375183,0.0001219388,0.00009837899,0.0001837906,0.00003202027,0.00002928104,0.00001446735,0.00007080266,0.0001252982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002987772,"about_ca_system_score_gemma":0.00006307867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001561076,"about_ca_topic_score_gemma":0.000001744789,"domain_scores_codex":[0.999101,0.00001247641,0.0002542498,0.0002423813,0.0001457628,0.0002441567],"domain_scores_gemma":[0.9994045,0.00004790883,0.00005808511,0.0003087787,0.00006760812,0.000113077],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001414011,0.0000608867,0.0003061611,0.001307476,0.00006329515,0.00001449756,0.00006945303,0.000003327125,0.9886764,0.00002114437,0.005656296,0.003679695],"study_design_scores_gemma":[0.001038121,0.0001180198,0.004818623,0.0001416632,0.0001699436,0.00001872716,0.0001159477,0.0001689382,0.9925435,0.0001600594,0.0005608446,0.0001456283],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997732,0.0004693853,0.00006271809,0.0008307635,0.00008403153,0.0003921435,0.00006012639,0.0001720203,0.0001968306],"genre_scores_gemma":[0.9914842,0.00002728844,0.0006651349,0.0001133781,0.0002430419,0.0001058718,0.000271751,0.00002772962,0.007061607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006864776,"threshold_uncertainty_score":0.497252,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03121711511255977,"score_gpt":0.2780686959870726,"score_spread":0.2468515808745128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}