{"id":"W4387769798","doi":"10.1021/acs.biochem.3c00337","title":"High-Affinity Fluorogenic Substrate for Tissue Transglutaminase Reveals Enzymatic Hysteresis","year":2023,"lang":"en","type":"article","venue":"Biochemistry","topic":"Blood properties and coagulation","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Tissue transglutaminase; Chemistry; Enzyme; Substrate (aquarium); Biochemistry; GTP'; Isozyme; Allosteric regulation; Biophysics; Combinatorial chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004410025,0.0008065657,0.0004518061,0.0002723192,0.0002083558,0.0002957582,0.0007272121,0.00100709,0.001927428],"category_scores_gemma":[0.0003459688,0.0002707109,0.000393266,0.0002818688,0.000320077,0.0003758526,0.0003465204,0.001153937,0.001184834],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005249775,"about_ca_system_score_gemma":0.0002867819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005397039,"about_ca_topic_score_gemma":0.0007641635,"domain_scores_codex":[0.999613,0.00009149844,0.00001673703,0.0001056186,0.00009475921,0.00007845496],"domain_scores_gemma":[0.9996896,0.0001226409,0.00004268328,0.00004137759,0.00005570034,0.00004813705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004357042,0.00002024237,0.00006631455,0.00005003847,0.000005306001,0.00006340034,0.0000122203,0.00006287744,0.9973315,0.0001551201,0.00009015269,0.002099321],"study_design_scores_gemma":[0.000006684523,0.0001114138,0.000234556,0.000004673818,0.000005382533,0.0001801541,0.000006456472,0.0005855953,0.9970552,0.00003500667,0.001769606,0.000005343835],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8050665,0.00986791,0.167903,0.0007261563,0.0002121783,0.0001705177,0.0005777994,0.001055885,0.01442007],"genre_scores_gemma":[0.9155729,0.003085139,0.07074633,0.0002922521,0.000039557,0.0001456942,0.001338019,0.00009337509,0.00868677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001927428,"threshold_uncertainty_score":0.006447911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03121711511255977,"score_gpt":0.2780686959870726,"score_spread":0.2468515808745128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}