{"id":"W4387771126","doi":"10.1186/s40170-023-00318-y","title":"Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition","year":2023,"lang":"en","type":"article","venue":"Cancer & Metabolism","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; James Tudor Foundation; University of Bristol; Diabetes UK; European Research Council; Cancer Research UK; World Cancer Research Fund; McGill University; Bowel and Cancer Research","keywords":"Glutaminase; Colorectal cancer; Aspirin; Cancer; Metabolism; Medicine; Cancer research; Internal medicine; Glutamate receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003460044,0.0004566777,0.0005827108,0.0001636148,0.0002248336,0.0001063451,0.0001860882,0.0002661232,0.00009564576],"category_scores_gemma":[0.00007609444,0.0004593577,0.0002065231,0.0006033516,0.0001693953,0.00003032139,0.0003243142,0.0001789605,0.00004395676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004271456,"about_ca_system_score_gemma":0.000268222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001970025,"about_ca_topic_score_gemma":0.00187318,"domain_scores_codex":[0.9972543,0.0001192774,0.0004059769,0.001082027,0.0003337341,0.0008047026],"domain_scores_gemma":[0.9986366,0.00001971489,0.0001561732,0.0004945644,0.0002432904,0.0004496287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002020096,0.00005129971,0.000253649,0.00006715437,0.0001083735,0.00001056763,0.0004835025,0.0001392299,0.8741703,0.0001546322,0.02008903,0.1042702],"study_design_scores_gemma":[0.0009831217,0.00004375433,0.01955388,0.00002724109,0.0001699738,0.00001339928,0.0002074239,0.0000188528,0.4141922,0.00005311883,0.5643092,0.0004278664],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9135693,0.08008643,0.00008044837,0.0005668066,0.003929551,0.0006552239,0.0005044757,0.0001394485,0.0004682555],"genre_scores_gemma":[0.9263391,0.05784865,0.0005463592,0.001978745,0.008317159,0.00115922,0.0002873491,0.0001419679,0.003381394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5442201,"threshold_uncertainty_score":0.9997858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01226694538470879,"score_gpt":0.2740718180348985,"score_spread":0.2618048726501897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}