{"id":"W4387773449","doi":"10.1016/j.chembiol.2023.08.017","title":"Targeting selective E3 ligase for healing cardiac fibrosis","year":2023,"lang":"en","type":"letter","venue":"Cell chemical biology","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Laurentian University","funders":"","keywords":"Ubiquitin ligase; Cardiac fibrosis; DNA ligase; Wound healing; Fibrosis; Medicine; Cell biology; Chemistry; Computational biology; Cancer research; Ubiquitin; Biology; Internal medicine; Surgery; DNA; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002049305,0.0007726192,0.0009685114,0.0004587819,0.002287789,0.002397934,0.0007787053,0.03009491,0.005259044],"category_scores_gemma":[0.006998859,0.0004446177,0.00108516,0.0002606147,0.001817198,0.001531893,0.001072122,0.01800244,0.00383712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003483924,"about_ca_system_score_gemma":0.001859163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001816247,"about_ca_topic_score_gemma":0.004586876,"domain_scores_codex":[0.9988497,0.000251429,0.0001043526,0.000148044,0.0004292767,0.0002172287],"domain_scores_gemma":[0.9982316,0.001075552,0.0001127933,0.00006406142,0.0002502465,0.0002657702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002055703,0.0001138666,0.0005075976,0.0001021041,0.00003563847,0.002133076,0.0000818993,0.0001766071,0.002122334,0.009905432,0.9542884,0.03032743],"study_design_scores_gemma":[0.0003629187,0.0002711764,0.0006490015,0.0001313866,0.00004630538,0.001838127,0.0001275041,0.001273021,0.002205296,0.01823801,0.9748072,0.000050044],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"editorial","genre_scores_codex":[0.001582965,0.00735542,0.0008518753,0.9462845,0.03337515,0.00005451639,0.0001252992,0.00009721325,0.01027308],"genre_scores_gemma":[0.02052245,0.006451717,0.001286916,0.8915895,0.04273438,0.0002184897,0.00009225772,0.00005687373,0.03704743],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.03009491,"threshold_uncertainty_score":0.02527773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01899358036132882,"score_gpt":0.272887652067156,"score_spread":0.2538940717058272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}