{"id":"W4387773652","doi":"10.1186/s13567-023-01221-6","title":"Exploring the alternative virulence determinants PB2 S155N and PA S49Y/D347G that promote mammalian adaptation of the H9N2 avian influenza virus in mice","year":2023,"lang":"en","type":"article","venue":"Veterinary Research","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"State Key Laboratory of Veterinary Biotechnology; Fundamental Research Funds for the Central Universities; National Key Research and Development Program of China; National Natural Science Foundation of China","keywords":"Biology; Virology; Influenza A virus subtype H5N1; Virulence; Host adaptation; Viral replication; Virus; Influenza A virus; Gene; Polymerase; Genetics; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009248187,0.0003048794,0.0001503915,0.0001547908,0.00008482083,0.0001539094,0.0001384211,0.0001839415,0.0005247971],"category_scores_gemma":[0.0000928392,0.0001196346,0.0002144201,0.0000633496,0.0001984198,0.00009558931,0.0001199999,0.0003484534,0.0001618926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001648617,"about_ca_system_score_gemma":0.0001693948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004583301,"about_ca_topic_score_gemma":0.0007116073,"domain_scores_codex":[0.9999274,0.00001637124,0.00000669061,0.00001417563,0.00001673173,0.00001868465],"domain_scores_gemma":[0.9999337,0.000009998605,0.00002576701,0.000006437001,0.000004431576,0.00001973061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009678747,0.00002001504,0.00049837,0.000007451968,0.000003078919,0.00004852713,0.000007233421,0.0000692995,0.9987032,0.00005275308,0.000005031466,0.000488209],"study_design_scores_gemma":[0.00004808451,0.001362268,0.017354,0.000009789413,0.0000337254,0.0005326495,0.00004400128,0.002066607,0.9771828,0.0001065365,0.001250672,0.000008831018],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987257,0.0001398453,0.0007192717,0.00001898422,0.00000474182,0.00001320952,0.00003493927,0.00001188715,0.0003313482],"genre_scores_gemma":[0.9982127,0.0001592475,0.001124372,0.00002727072,0.000003580905,0.00001420584,0.00007473956,0.00000711776,0.0003767967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005247971,"threshold_uncertainty_score":0.001755595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.6268149875727208,"score_gpt":0.4840138565444601,"score_spread":0.1428011310282607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}