{"id":"W4387781475","doi":"10.1101/2023.10.16.562554","title":"A 2-Hydroxybutyrate- mediated feedback loop regulates muscular fatigue","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Vetenskapsrådet; Cancerfonden; Wellcome Trust","keywords":"Skeletal muscle; Enzyme; In vivo; Metabolism; Metabolite; Chemistry; Exertion; Cell biology; Biochemistry; Internal medicine; Endocrinology; Biology; Genetics; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001507126,0.0003806798,0.0002660521,0.0001232701,0.0001622196,0.0004398557,0.0001514729,0.000281613,0.003059932],"category_scores_gemma":[0.0001142857,0.0001538989,0.0002764883,0.00007480377,0.0002173669,0.000234348,0.0003075861,0.000390908,0.0007773608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000224278,"about_ca_system_score_gemma":0.0001837376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005095259,"about_ca_topic_score_gemma":0.0005813869,"domain_scores_codex":[0.9999267,0.00001204912,0.00000367524,0.00002408366,0.00001358859,0.00001993953],"domain_scores_gemma":[0.9999489,0.000007167315,0.00001291159,0.000006552068,0.00001122419,0.00001330733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002215258,0.0000204028,0.0007562672,0.00003636059,0.00001111727,0.00006922062,0.00001910538,0.0003040414,0.9953995,0.0002274415,0.0001622593,0.002772685],"study_design_scores_gemma":[0.0001466233,0.0006164029,0.06344081,0.00006348664,0.0000682645,0.000444052,0.0001657708,0.0212105,0.9010332,0.002295195,0.01048274,0.00003294687],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9550169,0.005969563,0.03123658,0.0009656298,0.0004394776,0.0000482819,0.0008947755,0.0005824295,0.004846449],"genre_scores_gemma":[0.9890997,0.001114378,0.003399863,0.0001367473,0.00007687864,0.00003295136,0.0004330816,0.00004701622,0.005659468],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003059932,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03093888384048804,"score_gpt":0.2564303818242278,"score_spread":0.2254914979837397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}