{"id":"W4387797966","doi":"10.1158/2159-8290.cd-23-0984","title":"AMG 509 (Xaluritamig), an Anti-STEAP1 XmAb 2+1 T-cell Redirecting Immune Therapy with Avidity-Dependent Activity against Prostate Cancer","year":2023,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada)","funders":"","keywords":"Avidity; Prostate cancer; Immune system; Cancer; Prostate; Cancer research; Medicine; Cancer therapy; Immunology; Biology; Internal medicine; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004234388,0.000474019,0.000679546,0.0002603678,0.0003991614,0.0002047435,0.0002473714,0.0001477248,0.0001055364],"category_scores_gemma":[0.00001552983,0.0003349155,0.0001704592,0.0009135976,0.0002330286,0.001011967,0.0001244866,0.0006360097,0.00003865594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008255688,"about_ca_system_score_gemma":0.001543542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00286887,"about_ca_topic_score_gemma":0.0005956806,"domain_scores_codex":[0.996708,0.0001389929,0.0003275447,0.0009310967,0.0008757167,0.001018594],"domain_scores_gemma":[0.9984568,0.00008309304,0.0002066852,0.0007365868,0.0002042691,0.0003125802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007708415,0.001343637,0.2725859,0.0008262795,0.0009342695,0.001017165,0.003529661,0.001215636,0.5935082,0.00000883204,0.00236377,0.1149582],"study_design_scores_gemma":[0.01714935,0.001882795,0.4212711,0.001465313,0.0002575441,0.00002413096,0.0020624,0.0006627697,0.5479882,0.00004716295,0.006081628,0.00110761],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848009,0.008541536,0.000008356636,0.002004745,0.0007457954,0.001580992,0.0003603091,0.000366264,0.001591087],"genre_scores_gemma":[0.9389472,0.04049951,0.00002199589,0.0002253396,0.000625554,0.0009055215,0.0002302992,0.0001374687,0.01840708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1486851,"threshold_uncertainty_score":0.9999103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03907725534016136,"score_gpt":0.338504388889675,"score_spread":0.2994271335495136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}