{"id":"W4387797966","doi":"10.1158/2159-8290.cd-23-0984","title":"AMG 509 (Xaluritamig), an Anti-STEAP1 XmAb 2+1 T-cell Redirecting Immune Therapy with Avidity-Dependent Activity against Prostate Cancer","year":2023,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada)","funders":"","keywords":"Avidity; Prostate cancer; Immune system; Cancer; Prostate; Cancer research; Medicine; Cancer therapy; Immunology; Biology; Internal medicine; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001711379,0.0006815428,0.000610629,0.0004560763,0.0007650852,0.00148037,0.001516105,0.009931743,0.004409144],"category_scores_gemma":[0.002983182,0.0003788941,0.0005498205,0.0002672835,0.001975256,0.001403374,0.0008559696,0.01271846,0.003563753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00328613,"about_ca_system_score_gemma":0.001465998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004050162,"about_ca_topic_score_gemma":0.00823273,"domain_scores_codex":[0.9989857,0.0002590435,0.00006279803,0.0002493346,0.0003406063,0.0001025412],"domain_scores_gemma":[0.9984223,0.001049812,0.00009254083,0.00002868252,0.0002999647,0.0001067439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002942373,0.00006126881,0.0001738661,0.0004795115,0.00003674126,0.0006118762,0.00007677329,0.0002912317,0.003872927,0.004340354,0.9352337,0.05452753],"study_design_scores_gemma":[0.0002214336,0.0002463211,0.000555749,0.0003713017,0.00003505561,0.0004537855,0.0001022579,0.0003930298,0.003083483,0.003219916,0.9912747,0.00004308338],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.004151952,0.1373213,0.001508464,0.6778653,0.1578666,0.0002443406,0.0003615886,0.0002950194,0.02038538],"genre_scores_gemma":[0.02526106,0.08896993,0.0009701253,0.6830077,0.08647189,0.0003807896,0.0002108664,0.0001332803,0.1145943],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.009931743,"threshold_uncertainty_score":0.02384263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03907725534016136,"score_gpt":0.338504388889675,"score_spread":0.2994271335495136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}