{"id":"W4387805440","doi":"10.1093/jncics/pkad088","title":"Large-scale meta–genome-wide association study reveals common genetic factors linked to radiation-induced acute toxicities across cancer types","year":2023,"lang":"en","type":"review","venue":"JNCI Cancer Spectrum","topic":"Effects of Radiation Exposure","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University of Alberta","funders":"Instituto de Salud Carlos III; World Cancer Research Fund; Vedecká Grantová Agentúra MŠVVaŠ SR a SAV; Programme Grants for Applied Research; Medical Research Council; Ministry of Education, India; National Institutes of Health; Rijksuniversiteit Groningen; National Medical Research Council; National Research Foundation; National Institute for Health and Care Research; Generalitat de Catalunya; Cancer Research UK; Duke-NUS Medical School; Kræftens Bekæmpelse; Centres de Recerca de Catalunya; Wellcome Trust; Fundación Cellex","keywords":"Single-nucleotide polymorphism; Linkage disequilibrium; Medicine; Genetic association; Prostate cancer; Heritability; Missing heritability problem; Minor allele frequency; Genetics; Genome-wide association study; Genetic variation; SNP; Breast cancer; Oncology; Biology; Gene; Bioinformatics; Cancer; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006484895,0.001536425,0.003470133,0.002901142,0.0007330034,0.002081145,0.001254908,0.001071458,0.002067242],"category_scores_gemma":[0.01010212,0.0007479655,0.01630318,0.00524773,0.0004875347,0.0006407092,0.001254599,0.001442543,0.0001961535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007896248,"about_ca_system_score_gemma":0.001147431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007027873,"about_ca_topic_score_gemma":0.01088439,"domain_scores_codex":[0.995056,0.002233686,0.0005505352,0.001397513,0.0004573482,0.0003048584],"domain_scores_gemma":[0.9922694,0.004510904,0.001115721,0.001425653,0.0004142807,0.00026412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.003790991,0.00004822884,0.520695,0.002924908,0.4515105,0.0005528828,0.0001343584,0.002850101,0.003584557,0.0002757133,0.001403061,0.01222973],"study_design_scores_gemma":[0.0007580205,0.0005807125,0.4945259,0.0005506985,0.4939624,0.0008562345,0.0001873622,0.003315473,0.001232025,0.001308472,0.002658934,0.00006378326],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.805375,0.1714337,0.01247538,0.001655103,0.0004243012,0.0001667652,0.006369502,0.0004349343,0.001665352],"genre_scores_gemma":[0.9864246,0.00915968,0.00202286,0.0003075656,0.00009583227,0.00008976615,0.001613285,0.00006222386,0.0002241729],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.007027873,"threshold_uncertainty_score":0.0342958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05843978892121934,"score_gpt":0.4006123759815673,"score_spread":0.3421725870603479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}