{"id":"W4387806256","doi":"10.1021/acs.biomac.3c00603","title":"PEGylation of a Peptide-Based Amphiphilic Delivery Agent and Influence on Protein Delivery to Cells","year":2023,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Feldan (Canada); Institut National de la Recherche Scientifique","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada","keywords":"PEGylation; Chemistry; Internalization; Biophysics; Endosome; Peptide; Amphiphile; Cell-penetrating peptide; Gene delivery; Cytotoxicity; Micelle; Cytosol; In vitro; Biochemistry; Polyethylene glycol; Transfection; Cell; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001678511,0.0003044275,0.0001765053,0.00009406648,0.00007988169,0.0001388755,0.00009872016,0.000189477,0.0004136269],"category_scores_gemma":[0.000191687,0.00009603362,0.000166873,0.000141544,0.000155165,0.0001963488,0.0001226456,0.000227023,0.0001363894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001803653,"about_ca_system_score_gemma":0.0001645613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005319339,"about_ca_topic_score_gemma":0.0003711281,"domain_scores_codex":[0.9999186,0.0000183671,0.00001061376,0.00001946938,0.00001825218,0.00001470122],"domain_scores_gemma":[0.9999088,0.00002927631,0.00002468131,0.0000103689,0.00001391806,0.00001295167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005883273,0.00001211945,0.00006940273,0.00002653704,0.000002386673,0.00002242574,0.000009727562,0.00009399954,0.9990164,0.00002750692,0.000006542794,0.0006541223],"study_design_scores_gemma":[0.000004962924,0.0001753753,0.0008231989,0.000002725081,0.000006580716,0.00004584502,0.000005712073,0.0003889482,0.997926,0.000009206655,0.0006091051,0.000002309126],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961877,0.0009294194,0.002015996,0.00002682236,0.00001105216,0.00003292424,0.00008730666,0.00001943851,0.0006893671],"genre_scores_gemma":[0.9951673,0.001067125,0.002561457,0.00003944445,0.000006133107,0.0000388897,0.0001930013,0.00001396561,0.0009127809],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005319339,"threshold_uncertainty_score":0.001383722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01211653124249516,"score_gpt":0.2405658201913928,"score_spread":0.2284492889488977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}