{"id":"W4387808212","doi":"10.1016/j.annonc.2023.09.657","title":"481P Second generation oral selective estrogen receptor degraders (SERDs) in breast cancer: A systematic review and meta-analysis of clinical trials","year":2023,"lang":"en","type":"review","venue":"Annals of Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; St. Michael's Hospital; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Cochrane Library; Internal medicine; Oncology; Breast cancer; Meta-analysis; Adverse effect; Estrogen receptor; Nausea; Randomized controlled trial; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006079049,0.002041891,0.01242509,0.002459559,0.0003209769,0.002151756,0.001436817,0.00144995,0.004701711],"category_scores_gemma":[0.01086948,0.000961381,0.02124747,0.003388501,0.0005119652,0.001297391,0.001238128,0.001793413,0.0003452629],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001322583,"about_ca_system_score_gemma":0.001722989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003317636,"about_ca_topic_score_gemma":0.01231386,"domain_scores_codex":[0.9968844,0.001436314,0.0008105937,0.0003727446,0.0003548182,0.0001410653],"domain_scores_gemma":[0.9950444,0.003409153,0.001052601,0.0001543762,0.0002455825,0.00009400713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.007208739,0.00004785976,0.002553703,0.4356171,0.5139238,0.0001292357,0.00008654324,0.0005926007,0.0005448438,0.000177063,0.001140985,0.03797754],"study_design_scores_gemma":[0.002903722,0.0004585131,0.003876542,0.02136235,0.9668438,0.000121338,0.00005881868,0.0001566426,0.0001638301,0.0002597426,0.003761259,0.00003342409],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003679358,0.9951392,0.0002908803,0.0001066651,0.00008832012,0.0001221078,0.0003577333,0.00001586953,0.0001998772],"genre_scores_gemma":[0.109012,0.8870652,0.001488685,0.0009345007,0.0001417496,0.0003156729,0.0005579152,0.00002196386,0.0004623877],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01242509,"threshold_uncertainty_score":0.03214943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.6932043071277709,"score_gpt":0.6183950127801529,"score_spread":0.07480929434761807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}