{"id":"W4387809552","doi":"10.1016/j.annonc.2023.10.050","title":"LBA1 CheckMate 77T: Phase III study comparing neoadjuvant nivolumab (NIVO) plus chemotherapy (chemo) vs neoadjuvant placebo plus chemo followed by surgery and adjuvant NIVO or placebo for previously untreated, resectable stage II–IIIb NSCLC","year":2023,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Esophageal Cancer Research and Treatment","field":"Medicine","cited_by":100,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Medicine; Placebo; Nivolumab; Chemotherapy; Adjuvant; Neoadjuvant therapy; Internal medicine; Oncology; Cancer; Immunotherapy; Breast cancer; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001180465,0.001508656,0.002276412,0.0005092783,0.0004211901,0.001249564,0.001194291,0.001291667,0.009433919],"category_scores_gemma":[0.0009160985,0.0006530249,0.001932149,0.0003913126,0.001037673,0.0008079362,0.0003836714,0.003403847,0.001678807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001406113,"about_ca_system_score_gemma":0.00164545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002756699,"about_ca_topic_score_gemma":0.009537551,"domain_scores_codex":[0.999775,0.00008656208,0.00001066223,0.00005000912,0.00002072555,0.00005706278],"domain_scores_gemma":[0.9995081,0.000107546,0.00008725166,0.00003361427,0.00002512543,0.000238291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8798456,0.02890865,0.001636398,0.001743714,0.002360271,0.00005809802,0.0001164733,0.001690862,0.01799409,0.0004014948,0.00488783,0.06035654],"study_design_scores_gemma":[0.8204222,0.1698456,0.00381025,0.00007520329,0.00107902,0.00006799787,0.00004652218,0.000688507,0.001517451,0.0001752179,0.002241804,0.00003019592],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9806983,0.006404604,0.0005717825,0.0009915625,0.0008697602,0.002805898,0.00291042,0.0002540207,0.004493557],"genre_scores_gemma":[0.9749747,0.004764352,0.001882531,0.001817715,0.0004584824,0.003464061,0.004071792,0.00008547198,0.008480781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009433919,"threshold_uncertainty_score":0.03155965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1174064700800924,"score_gpt":0.4261141496413201,"score_spread":0.3087076795612277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}