{"id":"W4387809567","doi":"10.1016/j.annonc.2023.10.069","title":"LBA68 FLAURA2: Safety and CNS outcomes of first-line (1L) osimertinib (osi) ± chemotherapy (CTx) in EGFRm advanced NSCLC","year":2023,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Pemetrexed; Internal medicine; Oncology; Discontinuation; Chemotherapy; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000479257,0.0002276199,0.0005863953,0.000234189,0.0001940965,0.0007252037,0.0003041957,0.0004186305,0.003286303],"category_scores_gemma":[0.000824802,0.0001151961,0.0006196978,0.0002237191,0.0002584848,0.0004813408,0.0001987424,0.001219387,0.000646633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001117947,"about_ca_system_score_gemma":0.0007017119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001845162,"about_ca_topic_score_gemma":0.004583699,"domain_scores_codex":[0.9998011,0.00005518456,0.00001294788,0.00003605353,0.00004204884,0.00005256801],"domain_scores_gemma":[0.9996657,0.00006169307,0.0001196563,0.00002200624,0.0000309884,0.00009998429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.1692559,0.006283638,0.1321404,0.0008779214,0.002379589,0.000582868,0.0001740043,0.003351368,0.04445923,0.0007668101,0.01340044,0.6263279],"study_design_scores_gemma":[0.03986669,0.234528,0.6129413,0.0005877601,0.005759132,0.006934812,0.0006016043,0.01315122,0.0424337,0.002231284,0.04072972,0.0002346877],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930037,0.003295902,0.00009746258,0.0003941968,0.00005369593,0.00002958642,0.0005250589,0.00005535442,0.002545088],"genre_scores_gemma":[0.9969593,0.000812487,0.00009382281,0.0002362956,0.00005739897,0.00002487717,0.0007034729,0.00001241135,0.001099968],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003286303,"threshold_uncertainty_score":0.01099378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05048217222669842,"score_gpt":0.434699390876069,"score_spread":0.3842172186493706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}