{"id":"W4387809675","doi":"10.1016/j.annonc.2023.10.015","title":"LBA11 Datopotamab deruxtecan (Dato-DXd) vs chemotherapy in previously-treated inoperable or metastatic hormone receptor-positive, HER2-negative (HR+/HER2–) breast cancer (BC): Primary results from the randomised phase III TROPION-Breast01 trial","year":2023,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Foundation Medicine; Loxo Oncology; Jounce Therapeutics; Genentech; Gilead Sciences; Radius Health; MedImmune; Clovis Oncology; Eisai; Daiichi Sankyo Europe; Sanofi; Daiichi-Sankyo; Pfizer","keywords":"Medicine; Oncology; Metastatic breast cancer; HER2 negative; Internal medicine; Chemotherapy; Hormone receptor; Breast cancer; Cancer; Gynecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008983587,0.001073868,0.001509374,0.0002573833,0.0001733855,0.0008705897,0.000561711,0.0007748954,0.005955098],"category_scores_gemma":[0.000930539,0.0003100416,0.001188249,0.0003477418,0.0006352436,0.0006006469,0.0003188043,0.002376077,0.0007645546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009333916,"about_ca_system_score_gemma":0.0006753679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001533035,"about_ca_topic_score_gemma":0.004940047,"domain_scores_codex":[0.9996674,0.0001986792,0.00001076759,0.00004456162,0.00001917899,0.00005950132],"domain_scores_gemma":[0.9995542,0.0001443998,0.00009692806,0.00002700689,0.00001436073,0.000163013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9359836,0.003272335,0.001422813,0.0008591897,0.001239721,0.00005571881,0.00007410369,0.001832134,0.004649518,0.0003354675,0.002758492,0.04751686],"study_design_scores_gemma":[0.848263,0.1320331,0.01014994,0.0002012177,0.001626802,0.0001989159,0.0001115218,0.001674847,0.001302256,0.0007538719,0.003649806,0.00003463045],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860405,0.007383742,0.0002778199,0.0008509133,0.0003196989,0.0004651978,0.001280023,0.00007682644,0.003305386],"genre_scores_gemma":[0.9857672,0.004752609,0.0005325643,0.000910585,0.0001619546,0.0005040228,0.001922051,0.00002883436,0.005420171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005955098,"threshold_uncertainty_score":0.01992178,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06623516967856484,"score_gpt":0.4021662354896132,"score_spread":0.3359310658110483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}