{"id":"W4387810278","doi":"10.1016/j.annonc.2023.09.2742","title":"1792P Effects of enzalutamide on overall survival +/- early docetaxel in participants aged less than 70 yrs versus greater than or equal to 70 yrs in ENZAMET (ANZUP 1304)","year":2023,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency; University of Alberta; University of Ottawa","funders":"","keywords":"PTEN; Enzalutamide; Medicine; Oncology; Prostate cancer; Internal medicine; Proportional hazards model; Docetaxel; Multivariate analysis; Survival analysis; Overall survival; Cancer; Cancer research; Apoptosis; Androgen receptor; PI3K/AKT/mTOR pathway; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006839363,0.0003451798,0.0007441684,0.0001678023,0.0001519626,0.0003892799,0.0003310311,0.0004942983,0.007607579],"category_scores_gemma":[0.001306385,0.0001918547,0.001337319,0.0001881181,0.0001771545,0.0003735186,0.0003501541,0.001230978,0.0005347813],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003198506,"about_ca_system_score_gemma":0.0006840227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005207255,"about_ca_topic_score_gemma":0.009707802,"domain_scores_codex":[0.9996691,0.0001899576,0.00001571756,0.00004026747,0.00002689772,0.00005804568],"domain_scores_gemma":[0.9993302,0.0002295084,0.0001302818,0.00004411166,0.00004866705,0.0002172356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9006377,0.003188912,0.05098598,0.0002405163,0.002328704,0.0001165539,0.00005647872,0.0002497249,0.004015956,0.00009199561,0.003923118,0.03416425],"study_design_scores_gemma":[0.08905303,0.1543327,0.7440869,0.000132232,0.004691483,0.0001839835,0.0002634207,0.0009535261,0.001831576,0.0002678497,0.004159351,0.0000440374],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932634,0.001195678,0.00008094525,0.0002908636,0.0002155981,0.0001160713,0.002675983,0.00002330178,0.002138048],"genre_scores_gemma":[0.9939545,0.0004649647,0.0002234834,0.0003412763,0.00008678233,0.0001553474,0.001271344,0.000009711826,0.003492645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007607579,"threshold_uncertainty_score":0.02544987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2944132847888312,"score_gpt":0.4697874629469143,"score_spread":0.1753741781580831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}