{"id":"W4387811267","doi":"10.1016/j.annonc.2023.09.2157","title":"1018O Phase I study of GCC CAR-T therapy IM96 in patients with advanced colorectal cancer","year":2023,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Stephenson Cancer Center; Chugai Pharmaceutical; University of Texas MD Anderson Cancer Center; Genentech; Foundation Medicine; Sierra Oncology; INCLIVA Instituto de Investigación Sanitaria; Sun Pharma; PharmaMar; University of Toronto; European Society for Medical Oncology; FibroGen; Cytokinetics; Astellas Pharma; Eisai; Pfizer; Moderna; Incyte; BeiGene; Natera; Regeneron Pharmaceuticals; Daiichi Sankyo Europe; CRIS Cancer Foundation; Servier; Gilead Sciences; Ribon Therapeutics; Array BioPharma; Iterion Therapeutics; Sanofi; Amgen; G1 Therapeutics; Celgene; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Medicine; Rash; Mucositis; Gastroenterology; Internal medicine; Colorectal cancer; Phases of clinical research; Diarrhea; Toxicity; Adverse effect; Cancer; Oncology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007466606,0.0009615385,0.001288108,0.0003756097,0.0003433658,0.001043797,0.000565571,0.001215123,0.007455518],"category_scores_gemma":[0.0005025489,0.0003583019,0.001228703,0.0003654034,0.0006157978,0.0005172936,0.0003160666,0.003274226,0.00198565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006608747,"about_ca_system_score_gemma":0.0009420387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009327257,"about_ca_topic_score_gemma":0.001802477,"domain_scores_codex":[0.9997546,0.0001012401,0.000009882279,0.00004302728,0.00002035243,0.00007080333],"domain_scores_gemma":[0.9997422,0.00003992316,0.00002945853,0.00003148328,0.00001902842,0.0001378193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5193472,0.07470965,0.009475742,0.001448528,0.001773625,0.0007152749,0.0005720961,0.006488768,0.09413096,0.001039411,0.01199217,0.2783065],"study_design_scores_gemma":[0.3492781,0.6137682,0.009396309,0.00008230453,0.0006033416,0.0005526464,0.0001644908,0.002135675,0.009677085,0.0003553554,0.01394129,0.00004530716],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873821,0.002378146,0.0006401931,0.0009315603,0.0003057313,0.001707473,0.001582482,0.0001379052,0.004934474],"genre_scores_gemma":[0.9742215,0.002664379,0.00214784,0.001388867,0.0002011479,0.001991858,0.004282496,0.00005887256,0.01304304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007455518,"threshold_uncertainty_score":0.02494121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07137095289724445,"score_gpt":0.4252981760145111,"score_spread":0.3539272231172667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}