{"id":"W4387811483","doi":"10.1016/j.annonc.2023.09.1852","title":"666P Updated efficacy and safety data of entrectinib in patients (pts) with locally advanced/metastatic NTRK fusion-positive (fp) solid tumours","year":2023,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Roche (Canada)","funders":"Daiichi Sankyo Europe; National Evidence-based Healthcare Collaborating Agency; Mirati Therapeutics; Yuhan; F. Hoffmann-La Roche; AstraZeneca; Daiichi-Sankyo; Pfizer","keywords":"Medicine; Oncology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001566928,0.0003332965,0.001065863,0.000682973,0.0001674275,0.001076047,0.0004128774,0.0004573983,0.003225561],"category_scores_gemma":[0.002793633,0.0002130941,0.001238627,0.001098959,0.0002058199,0.0009741748,0.000380771,0.001258879,0.0007638995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009499445,"about_ca_system_score_gemma":0.0006435513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00123496,"about_ca_topic_score_gemma":0.003471057,"domain_scores_codex":[0.9992815,0.0001479276,0.000132899,0.0001034451,0.0002678416,0.00006647912],"domain_scores_gemma":[0.9979258,0.0006982581,0.0007620161,0.0001279215,0.0003544982,0.0001315028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1082783,0.0007534623,0.1285242,0.00545812,0.008051833,0.0008990705,0.0001756094,0.005595258,0.01642905,0.001280095,0.05296099,0.6715941],"study_design_scores_gemma":[0.02668419,0.01667924,0.6322595,0.002012207,0.018845,0.0048765,0.0002064268,0.003786012,0.01323782,0.002953908,0.2782241,0.000235074],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7946817,0.06850921,0.001791764,0.006290977,0.0009083051,0.0004030385,0.09277818,0.0003470242,0.03428979],"genre_scores_gemma":[0.8922524,0.02238153,0.001468126,0.003107277,0.0006988666,0.0002526752,0.073854,0.00008602156,0.005899244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003225561,"threshold_uncertainty_score":0.01079059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04426788104364964,"score_gpt":0.4159220113308469,"score_spread":0.3716541302871973,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}