{"id":"W4387812459","doi":"10.1016/j.annonc.2023.09.1327","title":"2300P Clonal hematopoiesis of indeterminate potential (CHIP) in patients with advanced NSCLC treated with immune checkpoint blockers (ICB) as monotherapy: Analysis of the PREMIS study","year":2023,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Cilag; Chugai Pharmaceutical; Genentech; Aptitude Health; Sierra Oncology; Eisai; Astellas Pharma; Basilea Pharmaceutica; Daiichi Sankyo Europe; Servier; AstraZeneca; Institut National Du Cancer; Pfizer; Incyte; BeiGene; Astex Pharmaceuticals; Les Laboratories Pierre Fabre; Ipsen; Jazz Pharmaceuticals; Bayer HealthCare; Exelixis; Sanofi; Amgen; American Association for Cancer Research; Eli Lilly and Company; Bristol-Myers Squibb; Agios Pharmaceuticals; Society for Immunotherapy of Cancer; PharmaMar; Celgene","keywords":"Medicine; Internal medicine; Oncology; Pembrolizumab; Lung cancer; Cancer; Immunotherapy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000477715,0.0001897316,0.001158766,0.0006128052,0.00004310508,0.000002380341,0.0002242235,0.00008058416,0.00004459895],"category_scores_gemma":[0.0001314063,0.0001115781,0.0001992207,0.00229502,0.0004038673,0.00005191744,0.0001364559,0.0001900511,0.000001027427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008395796,"about_ca_system_score_gemma":0.0002858412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001069419,"about_ca_topic_score_gemma":0.00060027,"domain_scores_codex":[0.9978605,0.0002118862,0.0006318213,0.0003018379,0.000661351,0.0003326074],"domain_scores_gemma":[0.9981998,0.0001450237,0.000516004,0.0004761911,0.0006031906,0.00005981594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01515619,0.002364523,0.9590853,0.0001379961,0.007313058,0.00005534019,0.003937123,0.000582303,0.004258946,0.000002741624,0.00006078567,0.007045732],"study_design_scores_gemma":[0.008552066,0.01289339,0.9510283,0.0001659113,0.0008412419,0.000001744525,0.001978268,0.0001198391,0.02427639,0.00001270306,0.0000314434,0.00009864134],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972332,0.0001278125,0.00000130512,0.001108323,0.00001942038,0.001170221,0.00003598283,0.00001616771,0.0002875472],"genre_scores_gemma":[0.9994709,0.0001316182,0.00006084263,0.00005193451,0.000007320547,0.00009687716,0.00001891154,0.00002186304,0.0001397115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02001745,"threshold_uncertainty_score":0.4550022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02526084698264695,"score_gpt":0.366198722378926,"score_spread":0.340937875396279,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}