{"id":"W4387812459","doi":"10.1016/j.annonc.2023.09.1327","title":"2300P Clonal hematopoiesis of indeterminate potential (CHIP) in patients with advanced NSCLC treated with immune checkpoint blockers (ICB) as monotherapy: Analysis of the PREMIS study","year":2023,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Cilag; Chugai Pharmaceutical; Genentech; Aptitude Health; Sierra Oncology; Eisai; Astellas Pharma; Basilea Pharmaceutica; Daiichi Sankyo Europe; Servier; AstraZeneca; Institut National Du Cancer; Pfizer; Incyte; BeiGene; Astex Pharmaceuticals; Les Laboratories Pierre Fabre; Ipsen; Jazz Pharmaceuticals; Bayer HealthCare; Exelixis; Sanofi; Amgen; American Association for Cancer Research; Eli Lilly and Company; Bristol-Myers Squibb; Agios Pharmaceuticals; Society for Immunotherapy of Cancer; PharmaMar; Celgene","keywords":"Medicine; Internal medicine; Oncology; Pembrolizumab; Lung cancer; Cancer; Immunotherapy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009192479,0.0003280969,0.000490453,0.0003896133,0.0002012003,0.0007022454,0.0004569597,0.0003406629,0.001022383],"category_scores_gemma":[0.001750663,0.0002355006,0.0005689744,0.0006369706,0.0002756173,0.0004131087,0.0004582908,0.0006043746,0.0001173098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002291236,"about_ca_system_score_gemma":0.0002678368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006039016,"about_ca_topic_score_gemma":0.001063804,"domain_scores_codex":[0.9996601,0.0001443083,0.00002709771,0.00007370256,0.00005710903,0.00003770884],"domain_scores_gemma":[0.998971,0.0003900531,0.0003123932,0.0001005299,0.00006894979,0.0001571056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01198466,0.0001629031,0.969191,0.0001029752,0.001266431,0.0002035802,0.00004988696,0.000276569,0.002445841,0.0002200454,0.000532683,0.01356337],"study_design_scores_gemma":[0.0009261841,0.002712806,0.9916363,0.00002280639,0.001300607,0.0006296893,0.00009849668,0.00061173,0.000516585,0.0002232561,0.001308461,0.00001311488],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980247,0.0008741658,0.00006737006,0.00004159072,0.000008009268,0.00001974341,0.0005008072,0.000002842613,0.0004608041],"genre_scores_gemma":[0.9987358,0.0002522158,0.00008614181,0.00005416688,0.00002588546,0.00002083962,0.0006933221,0.000002159893,0.00012945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001022383,"threshold_uncertainty_score":0.004861534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02526084698264695,"score_gpt":0.366198722378926,"score_spread":0.340937875396279,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}