{"id":"W4387812500","doi":"10.1016/j.annonc.2023.09.1267","title":"2239P Gene expression profiling in tumors with and without tertiary lymphoid structures across cancer-types","year":2023,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Cilag; Chugai Pharmaceutical; Foundation Medicine; Takeda Pharmaceuticals International; Sierra Oncology; INCLIVA Instituto de Investigación Sanitaria; Sociedad Española de Oncología Médica; PharmaMar; Novartis Farmacéutica; European Society for Medical Oncology; Fundación Científica Asociación Española Contra el Cáncer; Cancer Research UK; Seagen; F-star Therapeutics; Genentech; Veracyte; BeiGene; Mirati Therapeutics; Les Laboratories Pierre Fabre; Natera; Regeneron Pharmaceuticals; Ribon Therapeutics; Ipsen; Array BioPharma; Pfizer; Incyte; Grifols; F. Hoffmann-La Roche; Merck KGaA; Daiichi Sankyo Europe; Servier; Gilead Sciences; Astellas Pharma; FibroGen; Samsung; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; American Society of Clinical Oncology; Exelixis; Sanofi; Amgen; Celgene","keywords":"Medicine; CD19; Cancer; Tumor-infiltrating lymphocytes; Tumor microenvironment; Gene expression profiling; Gene signature; Pancreatic cancer; Colorectal cancer; Cancer research; Gene expression; Gene; Oncology; Internal medicine; Immunotherapy; Pathology; Immunology; Flow cytometry; Biology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001216815,0.0001619494,0.0002284622,0.0006752164,0.000311339,0.0005922096,0.0001462754,0.0003026007,0.003132779],"category_scores_gemma":[0.0003150585,0.000122401,0.0002978588,0.0005325822,0.0002743246,0.0001733614,0.0003725292,0.0004451679,0.0007563719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002347096,"about_ca_system_score_gemma":0.000208767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00133578,"about_ca_topic_score_gemma":0.001406583,"domain_scores_codex":[0.9997846,0.00001446154,0.00001289185,0.00006173195,0.00005827043,0.00006801196],"domain_scores_gemma":[0.9998647,0.00003368705,0.00003000357,0.00001214316,0.00003006728,0.00002933757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002688396,0.0000825953,0.08745608,0.0001345896,0.0001420067,0.0006006905,0.0002180072,0.0002796059,0.8933359,0.0003448918,0.0009332866,0.01378392],"study_design_scores_gemma":[0.00005389076,0.0004487539,0.8120295,0.00002942271,0.0002773714,0.003189324,0.001131309,0.001826475,0.1690883,0.0005853998,0.01131696,0.00002323749],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922768,0.0006082142,0.0008242019,0.0001006825,0.00002429069,0.00001836672,0.003723817,0.00005225421,0.002371493],"genre_scores_gemma":[0.9919487,0.0003728251,0.0005278297,0.0001054448,0.000008616534,0.00004343118,0.003912429,0.00003280934,0.003047877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003132779,"threshold_uncertainty_score":0.01048023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05125849636204086,"score_gpt":0.3995441698253357,"score_spread":0.3482856734632949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}