{"id":"W4387822491","doi":"10.1101/2023.10.17.562653","title":"A syngeneic spontaneous zebrafish model of <i>tp53</i> -deficient, EGFR <sup>vIII</sup> , and PI3KCA <sup>H1047R</sup> -driven glioblastoma reveals inhibitory roles for inflammation during tumor initiation and relapse <i>in vivo</i>","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Hospital for Sick Children","keywords":"Zebrafish; Cancer research; Biology; Tumor microenvironment; Immune system; Microglia; Innate immune system; Immunoediting; Inflammation; Immunology; Immunotherapy; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002344264,0.0008395723,0.0003850202,0.0007909077,0.0003895325,0.0003354793,0.0004789844,0.0007055797,0.002459951],"category_scores_gemma":[0.0001081423,0.0003514517,0.0005850869,0.0002462376,0.0006882118,0.0003285066,0.0003628892,0.001170684,0.0007290387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00097779,"about_ca_system_score_gemma":0.000834551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00541371,"about_ca_topic_score_gemma":0.008431455,"domain_scores_codex":[0.9997018,0.00001795425,0.00003584173,0.00008632724,0.00009298651,0.00006507577],"domain_scores_gemma":[0.9997436,0.00001691884,0.0001094385,0.00002610106,0.00002802779,0.00007589091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000682071,0.0000209425,0.0001081366,0.00002198193,0.00000437351,0.00009769256,0.00002088996,0.00006177231,0.9989643,0.0002177137,0.00006294075,0.0003509645],"study_design_scores_gemma":[0.00004043659,0.0004937775,0.00267583,0.00001314324,0.00003815866,0.0005295959,0.00005841401,0.001188634,0.9916075,0.00009311736,0.003245171,0.00001622629],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812354,0.0004591579,0.01056787,0.0002919346,0.0001162951,0.0002535353,0.003553111,0.0004871577,0.003035578],"genre_scores_gemma":[0.9687138,0.0007501057,0.01060827,0.0001265821,0.00001539563,0.0005018302,0.002463455,0.0002316769,0.01658891],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00541371,"threshold_uncertainty_score":0.01076442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01019639918491046,"score_gpt":0.2043143939629886,"score_spread":0.1941179947780782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}